lecture 9 ebola AFM Norovirus Flashcards
Marburg was identified in who?
green monkeys
how ismarburg spread? one concern was __
through body fluids; air travel
marburg treatment includes
supportive care but no drugs
what vax might work for marburg?
ebola vaccine
ebola is found in which locations?
sudan, congo, uganda, zaire
ebola tends to be in which reservoir?
bats, chimpanzees
how is ebola spread?
from bats to monkeys/antelopes to humans, or from bats to humans
marburg and ebola were found in which type of bat?
fruit bat
ebola marburg and lassa are what type of disease?
hemmorhhagic fever
locations where marburg happened
uganda, kenya
lassa happened where?
nigeria
lassa is a member of which virus family?
arenaviruses
why was the ebola outbreak in west africa different?
it was in cities nad not rural areas
how is lassa fever spread? and carried?
carried by rats in urine/feces, spread from human to human direct contact
avg percent mortality from lassa
1%
lassa incubation time
1-3 wk
drug to treat lassa
ribavirin but early on
symotoms of lassaf ever
fever, aches and pains
multi-organ failure
lungs, heart, GI tract, nerves
one effect of ebola onwest africa
destroyed the economy
mistakes made in sierra leone during ebola crisis
poor water sanitations, no body bags, inexperienced health care workers, weak leaders,power supply and funding low
what are Spread in health-care facilities where sterile materials
are at a premium. This is a major problem.
hemorrhagic viruses
marburg mort rate
25-90%
what was the source of the marburg virus and where?
Marburg Germany,from
green monkeys imported from Africa
where in the body do marburg symptoms show up?>
multiorgan issues
norovirus is mostly associated with hwhich place?
cruise ships
norovirus is ds/ss and DNA/RNA?
ss RNA
norovirus is very infectious T?F?
TRUE
symptoms of noroviorus
diarhhea, vomitting
how does norovirus spread?
fecal, oral, fomite, aerosol
how does norovirus spread?
person to enviroenment to person
how long does norovirus imunite last?
1 year, no permamanent
norovirus’s cycle lasts how long? which months?
1 year; Nov to May
what symptoms does ebola cause
general malaise, organ fail, death
mortality for ebola is low T/F?
FALSE
new version of ebola (2012) called
bundibugyo ebolavirus
bundibugyo ebola symptopms
fever, vomit, diarrhea, system fail
who got sick from ebola?
relatives, cotnacts, health care workers,
how did pekple outside of african coutnries contact ebola
travelling to africa and back home
post ebola virus syndrome
blind, eye issues, chronic pain, meningitis
in congo, ebola had a high coinfection with what
malaria
how people fought hte fear outbreak aspect of ebola
CUBE transparent tents and transparent body bags for peace of mind
the 12th wave of ebola affected who?
farmers and their wives
the distant cousin virys tio ebola is
lujo virus
what is lujo’s reservoir
rodents
tanzania had a similar ebola related symptom, what was it?
bleeding in the mouth
crimean congo hemorrhagic fever affected who?
epople who had direct contact w livestock
_%mort for crimean congo
30%
what was the vector for crimean congo fever?
ticks
define acute flaccid myelitis
sudden onset limp inflammation of spinal cord
who does AFM affect
kids
symptoms of AFM
weak muscle andreflexes, lost muscle tone, slurred speech,hard to wallow, facial droop
symptoms of AFM
weak muscle andreflexes, lost muscle tone, slurred speech,hard to wallow, facial droopse
severeAFM symptoms
the normal ones and then severe resp failure
diagnosing AFM is as easy as…!
MRI for lesions to spinal cord, high WBC, PCR for virus
AFM coud be caused by ?
enteroviruses, fever, mild respiratoru illness
AFM can cause this dieases which shows up in the body wehere?
polio in hand foot and mouth
the __ clade which causes AFM recocurs how often in the US?
d48; ever 2 years
what are similar syndroms to AFM?
polio, guillan barre, transverse myelitis
what are some similar toxins to AFM?
diptheria, botulinism, porphyria
how long after contracting norovirus fdoes disease happen?
within 24hr
what is an AFM treatment?
nerve transfers (they did em at St. Luke’e Hospital!)
severe cases of AFM are treated HOW?
MECHANIACAL VENTS
ways to treat AFM symptoms if not severe
phys/occupational therapy
how is bolivian hemmorhagic fever spread?
by mice
what virus causes bolivian hemmorhagic fever?
machupo virus
bolivian hemm fever is also called?
black typhus
how is bolivian hemm fever spread?
by mice (rarely human to human)
which is faster, D68 or polio?
polio
which is less virulent, D68 or polio?
D68
