lec 14- DNA viruses HPV and Herpes

Question 1

how many high school students are having sexual intercourse in the US?

Answer 1

over 1/3

Question 2

The leading STI’s in the US are

Answer 2

HPV and HSV2

Question 3

One virus infected cell lcan make how many viruses?

Answer 3

10^6

Question 4

Viruses must penetrate cells and host cells make more bc viruses donty have thei own

Answer 4

metabolic activity

Question 5

Most HPV infections are cleared by the immune system in how long?

Answer 5

2 years

Question 6

The prevalence of HPV is? And the incidence of HPV?

Answer 6

43 mil; 13 mil

Question 7

Descibe genome of HPV

Answer 7

Viruses are double stranded DNA viruses, capsid, no envelope, circular 8 genes

Question 8

How is HPV transmitted?

Answer 8

geneitcal contact, or nonsexual is from fomites or from mother to fetus

Question 9

Who mostly has HPV in the US?

Answer 9

teenagers

Question 10

Genital warts and the HPV genotypes that causes cancer are the same, T/F?

Answer 10

FALSE but there can be an association

Question 11

Detecting HPV in warts needs what methods?

Answer 11

visual insepction, biopsy, ELISA, DNA PCR and sequencing

Question 12

The treatment for HPV includes”

Answer 12

waiting for resolution or surgical removal

Question 13

genital warts Still have viral DNA and possibility for
recurrence after treatment T/F?

Answer 13

TRUE

Question 14

Who is at a higher risk for genital warts?

Answer 14

Males

Question 15

HPV responsible for: what types of cancers?

Answer 15

anal, crevical, vaginal, vulvar, oropharynx, penil ecancers

Question 16

How long does it take for precancer lesions to develop?

Answer 16

years

Question 17

What do PAP smears detect

Answer 17

pre tumors or tumors of cervical cancers

Question 18

The cancer causing strains of HPV are?

Answer 18

HPV 16 and 18

Question 19

The quadrivalent HPV vaccine is __. It prevents __

Answer 19

gardasil 9; prevents viruses from uncoatign and going itno the nucleus

Question 20

HPV strains that cause genital warts are?

Answer 20

6 and 11

Question 21

The HPV vaccine induces what? How long is it effective for?

Answer 21

more than 10 years; antibodies

Question 22

Who is recommended to be HPV vaccinated?

Answer 22

younger girls and boys before first intercourse

Question 23

How can the HPV vaccine help men?

Answer 23

prevent: gaymen anal warts, penile cancer, oral and head and neck cancers

Question 24

_ in _ cancers is caused by an infection and can be
treated or prevented

Answer 24

1 in 6

Question 25

Describe the genome of the herpes virus

Answer 25

Double stranded DNA, ~ 80 genes Circularizes in host nucleus

Question 26

Herpes Simplex 1 and 2 cause what issues?

Answer 26

oral and genital lesions

Question 27

How many human herpes viruses exist?

Answer 27

8

Question 28

How long does herpes virus last?

Answer 28

it is lifelong (chronic) and often cause latent reactivation

Question 29

herpes simplex is categoirzed how?

Answer 29

HSV1 and HSV2

Question 30

Both HSV1 and HSV2 cause chronic nerve cell infections, t/F?

Answer 30

TRUE

Question 31

What are the symptoms of both herpes simplex?

Answer 31

Symptoms include blisters, ulcers, rash

Question 32

Asymptomatic persons with hSV cannot transmit disease, T?F?

Answer 32

FALSE

Question 33

VR headsets could spread __ when gaming?

Answer 33

Ocular herpes

Question 34

HSV 1 was mostly transmitted how?

Answer 34

most infectedin childhood and reactivated later on

Question 35

HSV 1 transmission is how?

Answer 35

saliva, infection in ET->lesions in oral-> trigeminal nerves

Question 36

Severity of HSV1 is increased over time in reactivation, T/F?

Answer 36

FALSE, it goes down

Question 37

HSV disproportionately affects males, T/F?

Answer 37

False- equal between men and women but women are slightly more at risk

Question 38

HSV 2 symptoms include?

Answer 38

swole lymph nodes, fever, body aches, tingling, warming, shooting pain in legs/buttocks

Question 39

How is HSV 2 transmission done?

Answer 39

Instead of oral cells, it is through sexual contact with genital cels-> sacral nerves

Question 40

Type 2 HSV can cause ___

Answer 40

someoral cold sores

Question 41

Which herpes simplex has high genital recurrent episodes?

Answer 41

HSV 2

Question 42

The HSV2 disparity is in ?

Answer 42

14-49 year olds, black, female

Question 43

Diagnosis of HSV is doneby which methods?

Answer 43

Microscopy- host cell abnormalities * Tissue culture- HSV 1 & 2 easy to culture * Antibody tests - past exposure * PCR

Question 44

Treatment of HSV is done how?

Answer 44

there is no cure, so we supress symptoms through cyclovir types to inhibit DNA polymerases