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global health > lec 14- DNA viruses HPV and Herpes > Flashcards

lec 14- DNA viruses HPV and Herpes Flashcards

1
Q

how many high school students are having sexual intercourse in the US?

A

over 1/3

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2
Q

The leading STI’s in the US are

A

HPV and HSV2

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3
Q

One virus infected cell lcan make how many viruses?

A

10^6

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4
Q

Viruses must penetrate cells and host cells make more bc viruses donty have thei own

A

metabolic activity

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5
Q

Most HPV infections are cleared by the immune system in how long?

A

2 years

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6
Q

The prevalence of HPV is? And the incidence of HPV?

A

43 mil; 13 mil

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7
Q

Descibe genome of HPV

A

Viruses are double stranded DNA viruses, capsid, no envelope, circular 8 genes

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8
Q

How is HPV transmitted?

A

geneitcal contact, or nonsexual is from fomites or from mother to fetus

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9
Q

Who mostly has HPV in the US?

A

teenagers

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10
Q

Genital warts and the HPV genotypes that causes cancer are the same, T/F?

A

FALSE but there can be an association

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11
Q

Detecting HPV in warts needs what methods?

A

visual insepction, biopsy, ELISA, DNA PCR and sequencing

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12
Q

The treatment for HPV includes”

A

waiting for resolution or surgical removal

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13
Q

genital warts Still have viral DNA and possibility for
recurrence after treatment T/F?

A

TRUE

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14
Q

Who is at a higher risk for genital warts?

A

Males

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15
Q

HPV responsible for: what types of cancers?

A

anal, crevical, vaginal, vulvar, oropharynx, penil ecancers

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16
Q

How long does it take for precancer lesions to develop?

A

years

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17
Q

What do PAP smears detect

A

pre tumors or tumors of cervical cancers

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18
Q

The cancer causing strains of HPV are?

A

HPV 16 and 18

19
Q

The quadrivalent HPV vaccine is __. It prevents __

A

gardasil 9; prevents viruses from uncoatign and going itno the nucleus

20
Q

HPV strains that cause genital warts are?

A

6 and 11

21
Q

The HPV vaccine induces what? How long is it effective for?

A

more than 10 years; antibodies

22
Q

Who is recommended to be HPV vaccinated?

A

younger girls and boys before first intercourse

23
Q

How can the HPV vaccine help men?

A

prevent: gaymen anal warts, penile cancer, oral and head and neck cancers

24
Q

_ in _ cancers is caused by an infection and can be
treated or prevented

A

1 in 6

25
Q

Describe the genome of the herpes virus

A

Double stranded DNA, ~ 80 genes
Circularizes in host nucleus

26
Q

Herpes Simplex 1 and 2 cause what issues?

A

oral and genital lesions

27
Q

How many human herpes viruses exist?

A

8

28
Q

How long does herpes virus last?

A

it is lifelong (chronic) and often cause latent reactivation

29
Q

herpes simplex is categoirzed how?

A

HSV1 and HSV2

30
Q

Both HSV1 and HSV2 cause chronic nerve cell infections, t/F?

A

TRUE

31
Q

What are the symptoms of both herpes simplex?

A

Symptoms include blisters, ulcers, rash

32
Q

Asymptomatic persons with hSV cannot transmit disease, T?F?

A

FALSE

33
Q

VR headsets could spread __ when gaming?

A

Ocular herpes

34
Q

HSV 1 was mostly transmitted how?

A

most infectedin childhood and reactivated later on

35
Q

HSV 1 transmission is how?

A

saliva, infection in ET->lesions in oral-> trigeminal nerves

36
Q

Severity of HSV1 is increased over time in reactivation, T/F?

A

FALSE, it goes down

37
Q

HSV disproportionately affects males, T/F?

A

False- equal between men and women but women are slightly more at risk

38
Q

HSV 2 symptoms include?

A

swole lymph nodes, fever, body aches, tingling, warming, shooting pain in legs/buttocks

39
Q

How is HSV 2 transmission done?

A

Instead of oral cells, it is through sexual contact with genital cels-> sacral nerves

40
Q

Type 2 HSV can cause ___

A

someoral cold sores

41
Q

Which herpes simplex has high genital recurrent episodes?

A

HSV 2

42
Q

The HSV2 disparity is in ?

A

14-49 year olds, black, female

43
Q

Diagnosis of HSV is doneby which methods?

A

Microscopy- host cell abnormalities
* Tissue culture- HSV 1 & 2 easy to
culture
* Antibody tests - past exposure
* PCR

44
Q

Treatment of HSV is done how?

A

there is no cure, so we supress symptoms through cyclovir types to inhibit DNA polymerases

global health (29 decks)

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