lec 14- DNA viruses HPV and Herpes Flashcards
how many high school students are having sexual intercourse in the US?
over 1/3
The leading STI’s in the US are
HPV and HSV2
One virus infected cell lcan make how many viruses?
10^6
Viruses must penetrate cells and host cells make more bc viruses donty have thei own
metabolic activity
Most HPV infections are cleared by the immune system in how long?
2 years
The prevalence of HPV is? And the incidence of HPV?
43 mil; 13 mil
Descibe genome of HPV
Viruses are double stranded DNA viruses, capsid, no envelope, circular 8 genes
How is HPV transmitted?
geneitcal contact, or nonsexual is from fomites or from mother to fetus
Who mostly has HPV in the US?
teenagers
Genital warts and the HPV genotypes that causes cancer are the same, T/F?
FALSE but there can be an association
Detecting HPV in warts needs what methods?
visual insepction, biopsy, ELISA, DNA PCR and sequencing
The treatment for HPV includes”
waiting for resolution or surgical removal
genital warts Still have viral DNA and possibility for
recurrence after treatment T/F?
TRUE
Who is at a higher risk for genital warts?
Males
HPV responsible for: what types of cancers?
anal, crevical, vaginal, vulvar, oropharynx, penil ecancers
How long does it take for precancer lesions to develop?
years
What do PAP smears detect
pre tumors or tumors of cervical cancers
The cancer causing strains of HPV are?
HPV 16 and 18
The quadrivalent HPV vaccine is __. It prevents __
gardasil 9; prevents viruses from uncoatign and going itno the nucleus
HPV strains that cause genital warts are?
6 and 11
The HPV vaccine induces what? How long is it effective for?
more than 10 years; antibodies
Who is recommended to be HPV vaccinated?
younger girls and boys before first intercourse
How can the HPV vaccine help men?
prevent: gaymen anal warts, penile cancer, oral and head and neck cancers
_ in _ cancers is caused by an infection and can be
treated or prevented
1 in 6
Describe the genome of the herpes virus
Double stranded DNA, ~ 80 genes
Circularizes in host nucleus
Herpes Simplex 1 and 2 cause what issues?
oral and genital lesions
How many human herpes viruses exist?
8
How long does herpes virus last?
it is lifelong (chronic) and often cause latent reactivation
herpes simplex is categoirzed how?
HSV1 and HSV2
Both HSV1 and HSV2 cause chronic nerve cell infections, t/F?
TRUE
What are the symptoms of both herpes simplex?
Symptoms include blisters, ulcers, rash
Asymptomatic persons with hSV cannot transmit disease, T?F?
FALSE
VR headsets could spread __ when gaming?
Ocular herpes
HSV 1 was mostly transmitted how?
most infectedin childhood and reactivated later on
HSV 1 transmission is how?
saliva, infection in ET->lesions in oral-> trigeminal nerves
Severity of HSV1 is increased over time in reactivation, T/F?
FALSE, it goes down
HSV disproportionately affects males, T/F?
False- equal between men and women but women are slightly more at risk
HSV 2 symptoms include?
swole lymph nodes, fever, body aches, tingling, warming, shooting pain in legs/buttocks
How is HSV 2 transmission done?
Instead of oral cells, it is through sexual contact with genital cels-> sacral nerves
Type 2 HSV can cause ___
someoral cold sores
Which herpes simplex has high genital recurrent episodes?
HSV 2
The HSV2 disparity is in ?
14-49 year olds, black, female
Diagnosis of HSV is doneby which methods?
Microscopy- host cell abnormalities
* Tissue culture- HSV 1 & 2 easy to
culture
* Antibody tests - past exposure
* PCR
Treatment of HSV is done how?
there is no cure, so we supress symptoms through cyclovir types to inhibit DNA polymerases
