Lec 22 Heliobacter and GI tract Flashcards
The stomach lining is protected by
a mucus layer
What are ulcers linked to?
Excess acid in the stomach or duodenum
Severe cases of ulcers will causeq
hemorrhages and stomach contents to leak out
__ bacteria is highly associated with ulcrs
heliobacter pylori
Describe h pylori
g neg, spiral, flagella
Humans have different susceptibility to h pylori T/F?
TRUE
What is the job of h pylori; the endproducts are ___
Degrades proteins to make urea; alkaline
__% of people have h pylori in them
50
Risk factors for h pylori colonization are
poor SES, contamination, oral fecal contamination
Is h pylori colonization more likely to occur iun adults or kids?
kids
Early h pylori leads to __ while late leads to __
cancer; ulcers
Extreme high incidence of stomach cancer is in
Japan Chile and Iceland
HWhere are stomach cancer incidence rates higher in the US?
Alaska, Hawaii, New York, DC, Pennsylvania
WHo is stomach cancer most common in?
men over age 40
Helicobacter treatment includes
reducing salt and cured foods, vit C, radiation/chemo
Diagnosing h pylori
culture, antibody for history, detect urease breath test
Medicine to treat h pylori that got recalled is
zantac/ranitidine
We don’t treat heliobacter with antibiotics because
of resistance
What happens to alcoholics with h pylori>
alcoholic gastritis
Helicobacter treatment can regress inflammation of malt, lowering the risk for
lymphoma
Ulcers are linked to stomach cancers/ T/F?
FALSE, no evidence. only evidence that h pylori is related to both things.
Childhood infection can have what affect on adult infection?
limits acid production, but stomach cancer
Adult Childhood infection how many people get ulcers?
1/5
Acid from stomach irritates the esophagus in ___. It is a problem of the ___
GERD; Lower esophageal sphincter
GERD is associated with
hiatal hernia
Testing for GERD is done by
an endoscopy
How many americans have gerd?
20 million
FROm GERD you can advance to ___, and then __.
Barrett’s esophagus which is premalignant; esophageal cancer
Where are esophageal cancer rates high?
Asia, Africa
In chron’s disease, our immune system is doing what
reading food or something else for an issue (molecular mimicry)
Who is at higher risk of Chron’s
smoking Jews
Chron’s treatment is
treat symptoms with asprin and corticosteriods, surgery
Chron’s treatment is
treat symptoms with aspirin and corticosteriods, surgery
Chrons is most common in which areas
US, Canada, AUS, NZ
What is the relation of Gastric cancer to CHron’s?
Inverse relationship between incidence in different countries
Chron’s disease is possibly waht type of infection due to what bacteria?
zoonotic; m paratuberculosis (possibly correlated)
The end result of Chron’s is..
intense inflammation and discomfort
