lecture 2 -coronaviruses Flashcards
what protein is used to make DNA dependent viruses? this in which stage?
DNA DEPENDENT DNA POLYMERASE; DNA replication
WHat are the reverse transcribing viruses?
Hepadinaviridae, retroviridae
When RNA-depdendent DNA polymerases make mistakes, they create ____.
retroviruses
the flu virus families we are docusing on are
orthomyoxyviridae and coronaviridae(coronavirus)
mad cow and toxins are __
protien viruses
cell damage, loss of health by a
specific agent
disease
Growth or persistence of agent
WITHOUT disease/tissue damage
Colonization
Growth of the agent within a host
resulting in damage and disease
infection
Time from acquiring the
agent to the time that symptoms are
observed
Incubation period -
worldwide epidemic. Black
Death was a (endemic/epidemic/pandemic)
Pandemic
An increase in the number of
cases of a disease over that rate
usually found. A rapidly spreading new
disease. Swine Flu
epidmic
Commonly distributed in a
region. A common infection.
endemic
two or more people, in the same time and
place, with the same symptoms, must be more than
standard number who normally get the disease (food
poisoning versus seasonal flu)
outbreak
number of new cases of a disease.in a
given time period
incidence
total number of cases old and new.
The total number of ill people in the
population
prevalence
loss of life
mortality
loss ofhealth andnormal function
morbidity
DALY
measure of morbid and mortal related to a disease
AIDS is a syndrome T/F?
TRUE
A SYNDROME IS always a group of symptoms without a
known cause T/F?
FALSE- it couldddd but it also could have several known agents causing it
clinical criteria for coronaviruses
cough, fever, shortness of breath, and more
Diagnostic imaging criteria
for coronaviruses
Radiological evidence showing lesions compatible with
COVID-19
Three Point Response
to Disease
diagnostic test, treat with drug, immunize with vaccine
SARS was first diagnosed in a 48 yer old buisinessman travelling from __to__ to__
China to HK to Hanoi, Vietnam
Case definition of SARS includes
resp illness, fever, post 2003, travel or close cotnact in last 10 days
SARS IS Closely related to coronaviruses found in:
CIVET CATS, HORSESHOE BATS
describe SARS genome
ss + RNA
SARS is transmitted how>
air droplets, aerosols, fomites, fluids, endemic to animals
the SARS mortality rate is ?
9.6%
MERS-COV mortality rate is?
less than 50% (ABOUT 34%)
MERS COV is not human transmissable T/F?
TRUE
Who is affected most by SARS COV? what type of issues?
men; resp and kidney issue
the R factor for MERS COV now is? it USED to be?
less than 1; 2-4`
the reservoir for MERS COV is?
egyptian tomb bats, camels
the R value for COVID is?
2.5
MERS virus is grown how (to make vaccines)?
Virus grows in pig and bat cells
bsesides ppl who else needs to be immunized for MERS?
camels
describe the genome of COVID? (-/+) (small/large) (__kB) (#proteins)
+ ssRNA, large 30kB genome, 20-30proteins
How does COVID infect cells
enter through nose/mouth, infects airways
who in Human Genetics is moresusceptible to COVID?
NEANDERTHALS, EAST ASIANS,
ADULT COVID SYMPTOMS
New loss of taste or smell, amongst others
emergency warning signs for COVID-19:
T
Trouble breathing, Persistent pain or pressure in the
chest, New confusion, Inability to wake or stay awake,
Bluish lips or face
Dermatology symptoms of COVID19
COVID toes –
Red or purple toes,
Itchy hives,
Mottled bumps on fingers,
Lacy red rash that spread
across legs and arms
COVID Symptoms in Children
New loss of taste or smell.
Poor appetite or poor feeding, especially in babies under 1
year old
a small amount of children will develop __ from COVID
multisystem inflammatory syndrome (MIS-C)
can adults get MIS-C?
yes
intermediate host of COVID zoonosis
pangolin
what receptor is needed for the COVID lifestyle?
Ace2 angiotensin converting enzyme
