lecture 2 -coronaviruses Flashcards

1
Q

what protein is used to make DNA dependent viruses? this in which stage?

A

DNA DEPENDENT DNA POLYMERASE; DNA replication

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2
Q

WHat are the reverse transcribing viruses?

A

Hepadinaviridae, retroviridae

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3
Q

When RNA-depdendent DNA polymerases make mistakes, they create ____.

A

retroviruses

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4
Q

the flu virus families we are docusing on are

A

orthomyoxyviridae and coronaviridae(coronavirus)

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5
Q

mad cow and toxins are __

A

protien viruses

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6
Q

cell damage, loss of health by a
specific agent

A

disease

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7
Q

Growth or persistence of agent
WITHOUT disease/tissue damage

A

Colonization

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8
Q

Growth of the agent within a host
resulting in damage and disease

A

infection

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9
Q

Time from acquiring the
agent to the time that symptoms are
observed

A

Incubation period -

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10
Q

worldwide epidemic. Black
Death was a (endemic/epidemic/pandemic)

A

Pandemic

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11
Q

An increase in the number of
cases of a disease over that rate
usually found. A rapidly spreading new
disease. Swine Flu

A

epidmic

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12
Q

Commonly distributed in a
region. A common infection.

A

endemic

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13
Q

two or more people, in the same time and
place, with the same symptoms, must be more than
standard number who normally get the disease (food
poisoning versus seasonal flu)

A

outbreak

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14
Q

number of new cases of a disease.in a
given time period

A

incidence

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15
Q

total number of cases old and new.
The total number of ill people in the
population

A

prevalence

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16
Q

loss of life

A

mortality

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17
Q

loss ofhealth andnormal function

A

morbidity

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18
Q

DALY

A

measure of morbid and mortal related to a disease

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19
Q

AIDS is a syndrome T/F?

A

TRUE

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20
Q

A SYNDROME IS always a group of symptoms without a
known cause T/F?

A

FALSE- it couldddd but it also could have several known agents causing it

21
Q

clinical criteria for coronaviruses

A

cough, fever, shortness of breath, and more

22
Q

Diagnostic imaging criteria
for coronaviruses

A

Radiological evidence showing lesions compatible with
COVID-19

23
Q

Three Point Response
to Disease

A

diagnostic test, treat with drug, immunize with vaccine

24
Q

SARS was first diagnosed in a 48 yer old buisinessman travelling from __to__ to__

A

China to HK to Hanoi, Vietnam

25
Case definition of SARS includes
resp illness, fever, post 2003, travel or close cotnact in last 10 days
26
SARS IS Closely related to coronaviruses found in:
CIVET CATS, HORSESHOE BATS
27
describe SARS genome
ss + RNA
28
SARS is transmitted how>
air droplets, aerosols, fomites, fluids, endemic to animals
29
the SARS mortality rate is ?
9.6%
30
MERS-COV mortality rate is?
less than 50% (ABOUT 34%)
31
MERS COV is not human transmissable T/F?
TRUE
32
Who is affected most by SARS COV? what type of issues?
men; resp and kidney issue
33
the R factor for MERS COV now is? it USED to be?
less than 1; 2-4`
34
the reservoir for MERS COV is?
egyptian tomb bats, camels
35
the R value for COVID is?
2.5
36
MERS virus is grown how (to make vaccines)?
Virus grows in pig and bat cells
37
bsesides ppl who else needs to be immunized for MERS?
camels
38
describe the genome of COVID? (-/+) (small/large) (__kB) (#proteins)
+ ssRNA, large 30kB genome, 20-30proteins
39
How does COVID infect cells
enter through nose/mouth, infects airways
40
who in Human Genetics is moresusceptible to COVID?
NEANDERTHALS, EAST ASIANS,
41
ADULT COVID SYMPTOMS
New loss of taste or smell, amongst others
42
emergency warning signs for COVID-19: T
Trouble breathing, Persistent pain or pressure in the chest, New confusion, Inability to wake or stay awake, Bluish lips or face
43
Dermatology symptoms of COVID19
COVID toes – Red or purple toes, Itchy hives, Mottled bumps on fingers, Lacy red rash that spread across legs and arms
44
COVID Symptoms in Children
New loss of taste or smell. Poor appetite or poor feeding, especially in babies under 1 year old
45
a small amount of children will develop __ from COVID
multisystem inflammatory syndrome (MIS-C)
46
can adults get MIS-C?
yes
47
intermediate host of COVID zoonosis
pangolin
48
what receptor is needed for the COVID lifestyle?
Ace2 angiotensin converting enzyme