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global health > lecture 7 flu pandemics and hantavirus > Flashcards

lecture 7 flu pandemics and hantavirus Flashcards

1
Q

Flu genus is __.

A

orthomyoxiviridae

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2
Q

Flu genus is __.

A

orthomyoxiviridae

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3
Q

Hanta is in the genus ___.

A

Bunyaviridae

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4
Q

What three diseases are in the coronavirus genus?

A

SARS, MERS, SARS COV2

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5
Q

These types of influenza are cyclic?

A

A and B

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6
Q

is the Hanta mortality rate high or low? who is most affected?

A

low; young old and immune
compromised populations

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7
Q

hanta viral mutations caysed by what?

A

antigenetic drift

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8
Q

past exposure/vaccine to hanta can cause __. is this good or bad

A

pre-existing immunity; good

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9
Q

name a 20th century influenza pandemic. how many deaths?

A

spanish flu; 50 million

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10
Q

21st century pandemics 2 examples are?

A

swine flu and avian flu

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11
Q

what type of orthomyoxyviridae is the pandemic version?

A

type A

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12
Q

influenza type A uses what hosts/reservoirs?

A

animal/human

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13
Q

no pre pre-existing immunity to the novel viral variant causes what to rise?

A

higher mortality/hospitalizations: Young adults also affected

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14
Q
  • Mixing or swapping of genes between viruses requires (multiple/one) virus per cell? 2 names for the process are?
A

multiple; Antigenic Shift / Reassortment

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15
Q

how is novel virus named? do we have immunity to it?

A

for the H/N and the animal from
which the most genes came (swine, avian,
human); no

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16
Q

Changes in H and N proteins can affect?

A

Tissue and animal specificity

17
Q

the mixing bowl for disease is a nickname for this host/reservoir; T/F they can hold mult. viruses at once; name of this flu?

A

swine; T; H1N1 swine flu

18
Q

2004 - Avian flu (H5N1) outbreak has __% mortality. 2013 - Avian flu (H7N9) outbreak __% mortality

A

53%; 39%

19
Q

swine flu emerged in this year. who did it affect?

A

2009; kids and young adults, pregnant, immunocomp

20
Q

h1n1 is a __-reassortment virys

A

quadruple

21
Q

h1n1 had how much higher death rate vs seasonal flu (for young people)? percent deaths?

A

5x; 0.2

22
Q

h5n1 influenza killed __ and __. how was it transmitted?

A

birds and humans; direct or indirect contact with infected bird

23
Q

where was h7n1 focused in the world? what sympotms

A

china; pneumonia and severe resp illness

24
Q

bird flu 2 was in what year? what was the mortal rate? was it deadly to poultry?

A

2009; 39%; no

25
Q

source of Novel Flu Variants is; what kind of genetic shift happens there?

A

Wet Markets; reassortment

26
Q

besides wet markets, other sources for novel flus?

A

cock fights, conc. feeding

27
Q

what does hantavirus depend on? what body parts affected?

A

virus serotype (geographic factor);Affects endothelial cells- vascular system, the immune
system, respiratory system, kidneys

28
Q

diseases in hanta fam? names?

A

2; Hantavirus Pulmonary syndrome (HPS) or
Hemorrhagic fever with renal syndrome (HFRS)

29
Q

Hantavirus reservoirs are? thats why the other name is?

A

rodents; ‘Robovirus’

30
Q

where rodents live/nest can cause disease via what? who else is prone?

A

Aerosolizing viral-contaminated particles; hiker/camper

31
Q

a 69% mortality rate is in __ areas happening to strong health people? thisis in what forms of hanta?

A

rural; pulmonary and respiratory

32
Q

HPS is spread by _; name of this hantavirus is?

A

deer mouse; sin nombre hantavirus

33
Q

hps can be transmitted person to person T/F?

A

False- only mouse to human

34
Q

fever with chills, muscle aches and ___ are HPS symptoms

A

acute respiratory distress syndrome

35
Q

primary population affected byt HPS? where in the world?

A

usually healthy adults, white males; americas

36
Q

what is the prevention of hanta diseases?

A

avoid rodent exposure and seal food and hiding spots, stay protected

37
Q

low back and ab pain, and kidney failure are signs of?

A

hantarvirus hemmorhagic fever wth renal syndrome (HFRS)

38
Q

HFRS primarily affects _. mort rate is ?

A
  • Predominately farmers- young and old men; less than 15%
39
Q

how can one acquire HFRS?

A

increases in exposure to rat and mouse excreta

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