lecture 7 flu pandemics and hantavirus

Question 1

Flu genus is __.

Answer 1

orthomyoxiviridae

Question 2

Flu genus is __.

Answer 2

orthomyoxiviridae

Question 3

Hanta is in the genus ___.

Answer 3

Bunyaviridae

Question 4

What three diseases are in the coronavirus genus?

Answer 4

SARS, MERS, SARS COV2

Question 5

These types of influenza are cyclic?

Answer 5

A and B

Question 6

is the Hanta mortality rate high or low? who is most affected?

Answer 6

low; young old and immune
compromised populations

Question 7

hanta viral mutations caysed by what?

Answer 7

antigenetic drift

Question 8

past exposure/vaccine to hanta can cause __. is this good or bad

Answer 8

pre-existing immunity; good

Question 9

name a 20th century influenza pandemic. how many deaths?

Answer 9

spanish flu; 50 million

Question 10

21st century pandemics 2 examples are?

Answer 10

swine flu and avian flu

Question 11

what type of orthomyoxyviridae is the pandemic version?

Answer 11

type A

Question 12

influenza type A uses what hosts/reservoirs?

Answer 12

animal/human

Question 13

no pre pre-existing immunity to the novel viral variant causes what to rise?

Answer 13

higher mortality/hospitalizations: Young adults also affected

Question 14

• Mixing or swapping of genes between viruses requires (multiple/one) virus per cell? 2 names for the process are?

Answer 14

multiple; Antigenic Shift / Reassortment

Question 15

how is novel virus named? do we have immunity to it?

Answer 15

for the H/N and the animal from
which the most genes came (swine, avian,
human); no

Question 16

Changes in H and N proteins can affect?

Answer 16

Tissue and animal specificity

Question 17

the mixing bowl for disease is a nickname for this host/reservoir; T/F they can hold mult. viruses at once; name of this flu?

Answer 17

swine; T; H1N1 swine flu

Question 18

2004 - Avian flu (H5N1) outbreak has __% mortality. 2013 - Avian flu (H7N9) outbreak __% mortality

Answer 18

53%; 39%

Question 19

swine flu emerged in this year. who did it affect?

Answer 19

2009; kids and young adults, pregnant, immunocomp

Question 20

h1n1 is a __-reassortment virys

Answer 20

quadruple

Question 21

h1n1 had how much higher death rate vs seasonal flu (for young people)? percent deaths?

Answer 21

5x; 0.2

Question 22

h5n1 influenza killed __ and __. how was it transmitted?

Answer 22

birds and humans; direct or indirect contact with infected bird

Question 23

where was h7n1 focused in the world? what sympotms

Answer 23

china; pneumonia and severe resp illness

Question 24

bird flu 2 was in what year? what was the mortal rate? was it deadly to poultry?

Answer 24

2009; 39%; no

Question 25

source of Novel Flu Variants is; what kind of genetic shift happens there?

Answer 25

Wet Markets; reassortment

Question 26

besides wet markets, other sources for novel flus?

Answer 26

cock fights, conc. feeding

Question 27

what does hantavirus depend on? what body parts affected?

Answer 27

virus serotype (geographic factor);Affects endothelial cells- vascular system, the immune system, respiratory system, kidneys

Question 28

diseases in hanta fam? names?

Answer 28

2; Hantavirus Pulmonary syndrome (HPS) or Hemorrhagic fever with renal syndrome (HFRS)

Question 29

Hantavirus reservoirs are? thats why the other name is?

Answer 29

rodents; ‘Robovirus’

Question 30

where rodents live/nest can cause disease via what? who else is prone?

Answer 30

Aerosolizing viral-contaminated particles; hiker/camper

Question 31

a 69% mortality rate is in __ areas happening to strong health people? thisis in what forms of hanta?

Answer 31

rural; pulmonary and respiratory

Question 32

HPS is spread by _; name of this hantavirus is?

Answer 32

deer mouse; sin nombre hantavirus

Question 33

hps can be transmitted person to person T/F?

Answer 33

False- only mouse to human

Question 34

fever with chills, muscle aches and ___ are HPS symptoms

Answer 34

acute respiratory distress syndrome

Question 35

primary population affected byt HPS? where in the world?

Answer 35

usually healthy adults, white males; americas

Question 36

what is the prevention of hanta diseases?

Answer 36

avoid rodent exposure and seal food and hiding spots, stay protected

Question 37

low back and ab pain, and kidney failure are signs of?

Answer 37

hantarvirus hemmorhagic fever wth renal syndrome (HFRS)

Question 38

HFRS primarily affects _. mort rate is ?

Answer 38

* Predominately farmers- young and old men; less than 15%

Question 39

how can one acquire HFRS?

Answer 39

increases in exposure to rat and mouse excreta