Lec 25 Intestinal Diseases Flashcards
Colon contains how many microbes? How many cells are in our body?
10^14 microbes, 10^13 cells in body
Normal flora of GI tract do what jobs?
digestion, vitamin secretion, work immune system, prevent pathogens from growing
What is something that can disrupt normal flora?
antibiotics
House dust has the same microbes as
baby feces
Transmission of diarrhea is
fecal/oral or environmental/oral
Who is most affected with diarrhea?
children
Ecoli is a model organism that is a marker for what?
Coliform
Enterotoxigenic e coli ETEC is what?
traveler’s diarrhea
Enteroinvasive e coli EIEC is what?
bloody diarrhea that goes through intestine ET
Enteropathogenic E coli is what? EPEC
hospital baby diarrhea that has no toxin or invasion
Enterohemorrhagic E coli EHEC causes what?
Hemolytic uremic syndrome and kidney failure
EHEC is what strain? Where is it mostly present?
O157: H7; cattle (raw meat)
Classify vibrio cholera
g neg, toxin producing
Where is v cholera found?
brackish water (saltwater moving into freshwater or vice versa)
Cholera causes what symptoms?
severe dehydration because of lots of diarrhea. shock and throw up too
Which blood type is most susceptible to v cholera?
blood type O
Which blood type is least susceptible to v cholera?
blood type AB
Treatment of cholera includes?
IV, rehydration, support
Does a cholera vaccine exist?
Yes
Salmonella is __ so it is associated with___
zoonosis, turtles,chickens,eggs
Mortality for salmonella is __%
10
Does a salmonella vaccine exist?
Yes
Describe shigella?
g neg, produce toxin,
The g neg diseases intestinal are?
cholera, shigella, salmonella, campylobacter, c diff
Campylobacter is associated with
raw chicken, tap water etc
Describe c diff bacteria
anaerobic, makes spores, makes a toxin
C diff can cause what?
pseudomembranous colitis
Describe l monocytogenes, who is most susceptible?
g POS, pregnant women/elderly
Listeria is able to grow in which unexpected place?
the fridge
How do we treat bacterial intestinal infections?
fluid, sulfa drugs, anti-diarrheals
What are the viral intestinal diseases?
rotavirus, norovirus
Describe rotavirus makeup:
dsRNA
Where is rotovirus most common
south africa, asia, south india, south america
How can we diagnose rotavirus?
as an outbreak, viral antigens in ELISA
What are viruses that don’t make diarrhea but attack intestine?
Adeno and entero viruses, hep A and E
Individual prevention of intestinal diseases can be done by
handwashing, cooking meat, using CDC/FDA rules
You can get e coli 0157 H7, salmonella, and helminths from?
Beef
You can get l monocytogenes from?
Deli meats
You can get salmonella, campylobacter, helminths from?
Poultry
You can get v cholerae, typhoid, giardia, entameoba, helminths, cyrptosporidium
water
You can get salmonella , shigela, helminths, listeria, e coli 0157 H7 from?
Vegetables