Lecture 18- Drug Developmetn Flashcards

1
Q

Streptococcus and staphylococcus are gram negative/gram positive?

A

Gram positive

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2
Q

E. coli and salmonella are gram negative/gram positive?

A

Gram negative

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3
Q

Mycobacterium tuberculosis and spirochetes are ___ bacteria.

A

non-staining

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4
Q

Name two eukaryote parasites”

A

plasmodium which causes malaria, toxoplasma in cats

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5
Q

Name two eukaryotic fungi and molds

A

Candida and pneumocystis which causes pneumonia

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6
Q

Hep B and Herpes are which type of virus?

A

DNA virus

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7
Q

Hantavirus, polio, and the flu are which type of virus?

A

RNA virus

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8
Q

HIV iswhat type of virus?

A

retrovirus

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9
Q

Antibacterial drugs target what?

A

Antibacterial drugs target DNA replicationand unwinding.

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10
Q

The job of quinolones is to

A

Inhibit DNA from unwinding

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11
Q

The job of metronizadole is to

A

Bind and distort DNA

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12
Q

Which type of drugs target bacteria, yeasts, parasites,
living cells, but are usually not viral

A

Antibiotics

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13
Q

Is penicilin natural or synthetic? What about quinolones?

A

Penicilin is from common bread mold (natural), while quinolones are made (synthetic)

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14
Q

THe best activity against human cells is __x to __x above human activity against the pathogen.

A

100x to 1000x

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15
Q

Activity of drug against pathogen
versus
Activity of drug against human cells desribes the_____

A

Therapeutic index

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16
Q

You cannot use static and cidal drugs at the same time, T/F?

A

TRUE- one would inhibit and the other wouldn’t work

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17
Q

What are two ways drugs could be administered?

A

Oral or IV

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18
Q

Basic research in the __ stage is done with small molecules, genes, assays, drug targets

A

Drug discovery

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19
Q

Where is the ‘valley of death’ in drug development? How long of a stage is this?

A

Preclinical trials; 5-10 years

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20
Q

What is the issue with COVID drugs/trials?

A

time- becasuse existing drugs need to have later phases but we need them soon

21
Q

Generic drugs can be cheap because… And where is the intended market?

A

Their patent expired; USA

22
Q

Describe a human eukaryotic cell

A

Has a nucleus and other organelles in the cell

23
Q

Some antimicrobials are __

A

Antibiotic

24
Q

Which type of pathogen are drugs hardest to develop from?

A

Eukaryotic pathogens

25
Neuranimidase inhibitors are used for which pathogen drugs?
Flu drugs
26
Rifampiciin binds to an RNA polymerase which targets what stage?
Transcription (RNA produced from DNA)
27
When a cell membrane is targeted, what structures are important?
Lipids and polymyxins such as detergent
28
Vancomycin (last line of defense) interferes with ___
Cell wall integrity
29
Penicillin Cephalosporins Cephamycins interfere with
Cell wall synthesis
30
Low cost, low toxicity, low drug/drug interactions, broad spectrum are the:
Macrolides, penicillins, tetracyclines
31
In vitro is grown in a
test tube
32
n vivo is grown in
Humans or animals
33
if a drug doesn’t work in vitro, unlikely to be useful in vivo T/F?
True
34
TO understand a disease like cancer we need tyo consider at least two things:
Genetics and environment
35
Once we identify a target (which is usually?), we need to __ it.
A gene or protein target; validate (prove that inhibition will stop disease)
36
List 3 types of assays
enzyme, whole cell, fluorescent
37
High throughput screening (HTP) Biotechnology is used to find a __ compound. What type of therapeutic index does ithave?
Lead; good
38
To improve a drug, we start with lead compound, and modify chemically how
Structure activity relation, stability, absorption, therapeutic index, pathogen penetration
39
What occurs inthe preclinical development stage?
Animal models, drug metabolism ,safety assessment, pharmacy, process chem
40
GxP protocols include
good lab practice, manufacturing practice, clinical and regulatory practice
41
Early tests ADMA/Tox stands for
Absorption, distribution to site, metabolism into active state, excretion, non toxic
42
Dose, dosing interval, infusion rate, serum concentration fall under what category?
Pharmacokinetics
43
COVID animal testing was on which animals?
mice/rats, golden jhamster, ferret/mink, pigs, monkeuy
44
How long is a patent good for ?>
20 years
45
A drug needs o generate profit of how much above the cost of making and marketing?
$1 billion
46
There has been no new __ since the 1970s
avatar
47
Vioxx has a lawsuit. What did it seek to treat?
Arthitis
48
Torcetrapib was to treat what? It was a pfizer lawsuit.
Cholesterol