Exam 3 Imaging Intro, CT, & PET Flashcards

1
Q

Anatomical purpose of imaging

A

Location of masses or lesions within CNS

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2
Q

Functional purpose of imaging

A

Describe the location of brain activity associated with specific brain functions or dysfunction

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3
Q

Limitations of functional neuroimaging

A
  1. Physical properties of the recording system
  2. Physiological constraints of the brain
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4
Q

Only way meaning can be derived from images of brain activity

A

when acquired using the correct method and interpreted using the correct analyses

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5
Q

Two constraint based on resolution

A

Spatial resolution Temporal resolution

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6
Q

What is temporal resolution?

A

How close the timing between change in structure and behavior can be assessed

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7
Q

What is spatial resolution?

A

How accurate or specific can the neural structure or area associated with a behavior be located

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8
Q

Anatomical versus Functional constraints of imaging

A
  • -Most techniques give insight into anatomical relationships but not function.
  • -In those cases Function has to be derived from anatomical relationships.
  • -Some techniques do function measures such as measures of metabolic activity within the brain
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9
Q

Types of Imaging (9)

A
    1. Radiologic: Radiographs, Angiography, Computed Tomography (CT) scanning
    1. Positron Emission Tomography (PET scans)
    1. Single-photon emission computerized tomography (SPECT)
    1. Magnetic Resonance Imaging (MRI)
    1. Functional MRI (fMRI)
    1. Electroencephalography (EEG)
    1. Event related potentials (ERPs) & Evoked potentials (EPs)
    1. Magnetoencephalography (MEG)
    1. Near-infrared Spectroscopy
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10
Q

Disadvantage using of radiograph for the head

A

Check skull only

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11
Q

Advantages to using radiographs for skull (4)

A
  1. -Find fractures
  2. -Diseases that affect bones of the skull
  3. -Find a metallic foreign object stuck in the skull.
  4. -Check problems on a baby’s head, such as an odd shaped skull
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12
Q

What is radiograph of skull being replaced by

A

CT scans

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13
Q

What’s so great about Cerebral Angiography?

A
  1. Images of the vessels of the brain using a contrast medium
  2. Allowing detection of abnormalities such as arteriovenous (AV) malformations, occlusions and aneurysms
  3. Fluoroscopic angiography used for placement of endovascular coils for the treatment of aneurysms
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14
Q

What sucks about Cerebral Angiography?

A

Replaced by computed tomographic (CT) angiography for general diagnostics

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15
Q

What is Computed tomography (CT)? (3)

A
  1. -Computed Axial Tomography (CAT) scanning
  2. -Uses a series of x-rays of the head taken from many different directions
  3. -Typically used for quickly viewing brain injuries
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16
Q
A
17
Q

Types of views seen in CT

A

Horizontal, sagittal & coronal views

18
Q

Advantages of the CT

A

Useful for evaluating

  • Abnormal structures (tumors)
  • Swelling from tissue damage in the brain
  • Bleeding
  • Assessment of ventricle size

Modern CT scanning can provide reasonable images in minutes

Example of brain bleed

19
Q

Another example of CT of brain bleed

A
20
Q

Disadvantages of CT

A

relatively poor anatomical location

21
Q
A

These structures are:

    1. Septum pellucidum
    1. Internal capsule (anterior limb)
    1. Longitudinal fissure
    1. Caudate nucleus
    1. Putamen
    1. Thalamus
    1. Temporal horn of the lateral ventricle
    1. Internal capsule (posterior limb)
22
Q

What is Computed tomography angiography (CTA)?

A

–Enhancement of blood vessels of brain with contrast medium with ability of viewing vessels from horizontal, sagittal and coronal views
–Allows for precise localization of vascular lesions
–Allows for 3-D reconstruction
–Allows for 4-D assessment of blood flow in the brain

23
Q

Comparison of CTA with standard angiography

(just pic to look at)

A
24
Q

Advantages of Computed tomography angiography (CTA)

A
  1. Multidimensional perspective
  2. enhanced detail with 3-D CTA where you can remove other brain tissue to enhance the vessels
  3. Spot the aneurysm
  4. Ability to rotate image with 3-D CTA
  5. Ability to do precise measurement with 3-D CTA
25
Q

My advice to you about this power point (CT ppt)

A

Difficulty getting all the pics in, probably want to pull up the power point so that it makes more sense.

26
Q

What is Positron Emission Tomography (PET)?

A
  • -Produces a 3-D image of sites of elevated metabolism in the brain
  • -Detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is infused attached to fludeoxyglucose (FDG), a glucose analogue
    • Differences in brain activity can be assessed by differences in accumulation of FDG in different brain regions
27
Q

Tracers found in PET?

A

Specific radioligands for dopamine, serotonin & acetylcholine receptors & transporters for neurological and psychiatric disorder assessment

28
Q

What can PETs also detect?

A

Specific ligands for amyloid plaques – in vivo assessment in Alzheimer’s disease