Congenital Toxoplasmosis Flashcards

1
Q

What is toxoplasmosis caused by?

A

Protozoan parasite Toxoplasma Gondii

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2
Q

Where is toxoplasma gondii found?

A

Cat faeces

Undercooked meat

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3
Q

When does toxoplasmosis usually occur after ingestion?

A

Within 3 weeks of ingestion

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4
Q

How does toxoplasma gondii spread from mother to baby?

A

Trans-placentally

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5
Q

How does toxoplasmosis present in adults mainly?

A

Asymptomatically

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6
Q

How can toxoplasmosis present in adults?

A

Mild flu-like symptoms

fever, sore throat, Coryza, Arthralgia

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7
Q

What can happen if a woman becomes infected with toxoplasmosis while pregnant?

A

The infection can spread to the fetus and cause congenital toxoplasmosis

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8
Q

When is the risk of congenital toxoplasmosis higher?

A

When the infection is caught while the woman is pregnant rather than before

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9
Q

How do babies with congenital toxoplasmosis usually present?

A

They have no symptoms at birth

Can develop complications later in life

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10
Q

What are possible maternal complications of toxoplasmosis?

A

Chorioretinitis
Encephalitis
Myocarditis
Pneumonitis

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11
Q

What are possible fetal neurological complications of congenital toxoplasmosis?

A

Cerebral palsy
Cerebral calcifications
Hydrocephalus
Chorioretinitis

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12
Q

What are fetal ophthalmic complications of congenital toxoplasmosis?

A

Retinopathy

Cataracts

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13
Q

What can infection of congenital toxoplasmosis in the third trimester cause?

A

Increased risk of miscarriage and intrauterine death

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14
Q

Becoming infected with toxoplasmosis in which trimester leads to a worse outcome?

A

Becoming infected in the first trimester

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15
Q

How can a neonatal congenital toxoplasmosis infection be diagnosed?

A

With amniocentesis

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16
Q

What would you test for in the mother to check for previous exposure to toxoplasmosis?

A

Maternal IgM

17
Q

What is the medical management of congenital toxoplasmosis?

A

Combination of:
Pyrimethamine
Sulfadiazine
Folinic acid

18
Q

How long would you give medication for congenital toxoplasmosis for?

A

4-6 weeks

19
Q

What medication would you add on during pregnancy?

A

Spiramycin