African Sleeping Sickness Flashcards

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1
Q

What are the causative organisms of African Sleeping Sickness?

A

Trypanosoma brucei subspecies. gambiense or rhodesiense

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2
Q

What are Trypanosoma brucei subspecies gambinese or rhodesiense?

A

Prions

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3
Q

What are the most common modes of transmission?

A

Vector, vertical

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4
Q

What are the virulence factors for Trypanosoma brucei subspecies gambienses or rhodesiense (Afrrcan Sleeping Sickness)?

A

Immune evasion by antigen shifting

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5
Q

How do you culture/diagnose Trypanosoma brucei subspecies gambiense or rhodesiense (African Sleeping Sickness)?

A

Microscopic examination of blood, CSF

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6
Q

How do you prevent Trypanosoma brucei subspecies gambiense or rhodesiense (African Sleeping Sickness) infection?

A

Vectorr control

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7
Q

How do you treat Trypanosoma brucei subspecies gambiense or rhodesiense (African Sleeping Sickness) infection?

A

Suramin or pentamidine (early), eflornithine or melarsoprol (late)

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8
Q

What are the epidemiological features of Trypanosoma brucei subspecies gambiense or rhodesiense?

A

T. brucei gambiense: 7,000-10,000 cases reported annually; actual occurrence estimated at 600,000;
T. brucei rhodesiense: estimated 30,000 cases occur annually

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