acute inflammation

Question 1

When does acute inflammation occur

Answer 1

in response to injury
necrosis of any cause

Question 2

what are responses drive acute inflammation

Answer 2

vascular changes
cellular changes
chemical mediators

Question 3

What vascular changes occur

Answer 3

change in flow
vasodilation

Question 4

What chemicals mediate vascular changes

Answer 4

histamine
nitric oxide

Question 5

What cellular changes occur in response to injury

Answer 5

stasis
white cell margination
rolling of WBC

Question 6

How does cell margination occur

Answer 6

WBC roll along vessels
vessel epithelium express receptors for proteins on WBC
latch on

Question 7

Why does the permeability of blood vessels increase

Answer 7

so white blood cells can leave the vessels

Question 8

How are blood vessels made leaky

Answer 8

endothelial cell contraction
transcytosis

Question 9

How does endothelial cell contraction allow WBC to leave vessels

Answer 9

forms gaps between cells

Question 10

what is transcytosis

Answer 10

white blood cells squeeze through

Question 11

How are new vessels made

Answer 11

vascular endothelial growth factor (VEGF)

Question 12

How do white blood cells find site of inflammation

Answer 12

chemotaxis

Question 13

How do chemotaxis work

Answer 13

white blood cells become sniffer dogs and follow the chemical gradient

Question 14

what are the complement chemokines

Answer 14

c3a
c5a

Question 15

what are the clinical features of acute inflammation

Answer 15

tumour
rubor
loss of function

Question 16

why do tumours form

Answer 16

swelling due to vascular changes

Question 17

what chemical mediates pain

Answer 17

prostaglandins

Question 18

what cell will most likely be seen during inflammation

Answer 18

neutrophil