Abnormalities of the urogenital tract Flashcards

1
Q

What are some common causes of umbilical swellings?

A

Defect in umbilical wall → Failure of umbilical ring closure → Herniation

Infection of umbilical structures → Involves internal abdominal components

Persistent Urachus → Communication remains between bladder & umbilicus

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2
Q

What are the main causes of umbilical hernias?

A

Mostly congenital (potential hereditary link), some acquired but usually present at birth

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3
Q

How can umbilical hernias be classified?

A

Simple vs. Strangulated (strangulated requires emergency intervention)

Reducible vs. Irreducible (irreducible can lead to complications)

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4
Q

When can simple umbilical hernias be repaired?

A

Often corrected during routine neutering if they don’t resolve on their own

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5
Q

What are the signs of a strangulated hernia?

A

Failure to suckle, vocalisation, sepsis markers, severe pain

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6
Q

What are the main characteristics of umbilical hernias?

A

Soft tissue swellings, typically consistent in size, some may self-resolve, others require intervention

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7
Q

How does hernia size impact treatment decisions?

A

Small: Likely to resolve naturally, monitor

Medium: Highest strangulation risk, careful monitoring needed

Large: Unlikely to resolve, often requires surgery

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8
Q

What diagnostic tool can help assess umbilical hernias?

A

Ultrasound – useful for evaluating contents and severity

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9
Q

What are the treatment options for umbilical hernias?

A

Monitor small hernias.

Constriction bands (e.g. lamb rings) for fibrosis & closure

Surgery for persistent, large, or strangulated hernias

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10
Q

What is the key surgical approach for umbilical hernias?

A

Dissect down to hernia ring, return peritoneum to abdomen, & securely close defect

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11
Q

What is a patent urachus?

A

Failure of fetal urachus (connection between bladder & umbilicus) to close at birth, leading to urine leakage

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12
Q

What is the most obvious clinical sign of a patent urachus?

A

Dribbling urine from umbilicus

Posturing to urinate but failing

Pain & infection due to persistently wet environment

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13
Q

What complications can arise from a patent urachus?

A

Infection spreading to nearby tissues

Urachal cysts at bladder apex

Urethral diverticula

Uroperitoneum (if bladder drains into abdomen)

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14
Q

What is the primary surgical treatment for a patent urachus?

A

Resection back to bladder, inversion of bladder tissue & closure

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15
Q

What are the conservative treatment options for a patent urachus?

A

Astringents (iodine, silver nitrate) to induce fibrosis

Broad-spectrum antibiotics for infection

Clamps to encourage closure via scarring

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16
Q

What is Meckel’s diverticulum?

A

Remnant of vitelline duct, can cause intestinal strangulation, requiring surgical resection

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17
Q

What are the three key structures associated with umbilical infections?

A

Umbilical vein (to liver), umbilical arteries (to aorta), urachus (to bladder)

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18
Q

Define omphalophlebitis.

A

Infection of umbilical vein, leading to potential liver involvement

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19
Q

Define omphaloarteritis.

A

Infection of 1 or both umbilical arteries, connecting to aorta

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20
Q

What is urachal sepsis, and why is it concerning?

A

Infection of urachus, potentially leading to bladder infections & sepsis

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21
Q

Why is it important to differentiate types of umbilical infections?

A

Each type affects different structures, requiring specific treatment approaches to prevent systemic sepsis

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22
Q

What are the key clinical signs of an umbilical infection?

A

Localised swelling, pain, pus discharge & potential systemic illness (sepsis signs)

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23
Q

How can ultrasound aid in diagnosing umbilical infections?

A

Helps identify which umbilical structures are involved (vein, artery, urachus)

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24
Q

What systemic complications can arise from umbilical infection?

A

Septicaemia & joint ill (synovial sepsis) from bacterial spread

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25
Q

What is the first step in preventing umbilical infections in neonates?

A

Applying antiseptic solutions to umbilicus immediately after birth

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26
Q

What are the key treatment options for umbilical infections?

A

Antibiotics for systemic infection

Drainage of abscesses

Marsupialisation or surgical resection for severe cases

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27
Q

Define renal failure

A

Loss or urine concentrating ability

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28
Q

What is the earliest functional loss seen in renal failure?

A

Loss of urine concentrating ability occurs first, leading to polyuria

> 66% functional nephron loss

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29
Q

What is the USG threshold indicating renal failure?

A

Dogs: USG < 1.030
Cats: USG < 1.035

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30
Q

At what nephron loss percentage do waste products start accumulating in the blood?

A

> 75% nephron loss leads to persistent renal azotaemia (high urea & creatinine)

Both kidneys must be affected

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31
Q

What is SDMA, and why is it useful in renal failure?

A

Early marker of renal failure

Increases when >25% nephron loss has occurred, making it more sensitive than urea:creatinine

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32
Q

What defines chronic kidney disease (CKD)?

A

Functional or structural changes in one or both kidneys persisting for >3 months

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33
Q

Why is CKD often diagnosed late?

A

It is clinically silent until 66-75% of nephrons are lost, making early detection difficult

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34
Q

Is CKD more common in younger or older animals?

A

More common in older animals, especially cats

(30-50% of cats >15 years have CKD)

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35
Q

What happens initially when CKD develops?

A

Nephrons are destroyed & remaining nephrons hypertrophy to compensate

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36
Q

Is CKD progression the same in cats and dogs?

A

No, cats tend to have stable disease for longer, while dogs progress more rapidly

37
Q

What happens in the end stage of CKD, regardless of the initial cause?

A

Fibrosis (scar tissue) replaces functional nephrons, leading to irreversible kidney damage

tubulointerstitial nephritis (seen on histology)

38
Q

What is acute kidney injury (AKI)?

A

Sudden kidney damage that may be reversible, progressive, or fatal

39
Q

How can AKI lead to chronic kidney disease (CKD)?

A

Progressive loss of nephrons in AKI can cause permanent damage, leading to CKD

40
Q

What is “acute on chronic kidney disease”?

A

AKI occurring in patient with pre-existing CKD, worsening kidney function

41
Q

Why is early diagnosis of AKI crucial?

A

Helps limit disease progression & improves chance of reversibility

42
Q

Why is AKI prevention important in emergency and critical care patients?

A

Many critical patients are hypovolaemic or hypotensive, reducing kidney perfusion

Preventing renal hypoperfusion is key to avoiding AKI

43
Q

When should we suspect AKI in a sick patient?

A

Any increase in creatinine, even within normal range, can indicate early AKI

44
Q

What conditions can lead to poor renal perfusion and AKI?

A

Cardiovascular disease
Severe hypoxia
Critical illness/emergency cases

45
Q

What are common nephrotoxins that cause AKI?

A

Ethylene glycol (antifreeze) → More common in cats

Lily toxicity → Cats only

Grape/raisin toxicity → Dogs only

Vitamin D supplements/human psoriasis creams

NSAIDs → High doses, esp. in dehydrated patients

46
Q

Why is ethylene glycol (antifreeze) a key nephrotoxin?

A

It metabolises into toxic compounds, leading to severe kidney damage—often fatal if untreated

47
Q

Why is dehydration a risk factor for NSAID-induced AKI?

A

NSAIDs reduce renal prostaglandin production, impairing blood flow to kidneys, worsening dehydration effects

48
Q

How does obstructive disease cause AKI and what are the 2 types?

A

Blockage of urine flow increases pressure, leading to kidney damage

Urethral obstruction → Both kidneys affected

Ureteric obstruction → One kidney affected (usually)

49
Q

What are common causes of urinary obstruction leading to AKI?

A

Calculi (stones)
Blood clots
Neoplasia (tumours blocking urine flow)

50
Q

How can infections lead to AKI?

A

Localised infection → Ascending UTI infects renal pelvis (pyelonephritis)

Systemic infections → Cause direct kidney damage (e.g. leptospirosis in dogs, FIP in cats)

51
Q

How does hypercalcemia cause AKI?

A

Excess calcium deposits in kidneys, leading to nephron damage & impaired function

52
Q

What is “Alabama rot,” and how does it relate to AKI?

A

Cutaneous & renal glomerular vasculopathy

Unknown cause

Affects dogs → causes skin lesions + severe AKI (often fatal)

53
Q

Why is there often no definitive diagnosis (underlying cause) for CKD?

A

CKD is end-stage result of multiple disease pathways, with no clear initial cause in many cases

54
Q

What are some familial renal diseases that cause CKD?

A

Juvenile nephropathy → Boxer dogs

Renal dysplasia → Shih Tzu, Lhasa Apso, Golden Retriever

Amyloidosis → Shar Pei, Abyssinian cats

Polycystic kidney disease (PKD) → Persian & related breeds (autosomal dominant trait)

55
Q

How can immune-mediated disease cause CKD?

A

Glomerulonephritis (Type III hypersensitivity) leads to immune complex deposition in glomerulus, causing glomerular damage & protein loss (protein losing nephropathy)

56
Q

What vascular issues can cause CKD?

A

Ischaemia (restricted blood flow)

Renal infarcts (areas of dead tissue due to blood supply loss)

Vascular injury (damaged blood vessels lead to hypoxic damage in kidneys)

57
Q

How is CKD typically managed?

A

Managing consequences (e.g. controlling blood pressure, proteinuria) rather than treating (usually unknown) primary cause

58
Q

What factors in signalment and history increase suspicion of renal disease?

A

Young animal → Possible familial renal disease

Old cat → Increased risk of CKD

History of toxin exposure (e.g. ethylene glycol)

Use of nephrotoxic drugs (e.g. NSAIDs in dehydrated animals)

59
Q

What systemic illnesses can target the kidneys and cause failure?

A

FIP or lymphoma (cats)

Leptospirosis (dogs) → Also causes hepatitis

Severe illness causing hypovolemia/hypotension (e.g. pancreatitis, trauma, post-RTA)

60
Q

How does hypovolaemia contribute to renal failure?

A

Low blood volume reduces renal perfusion, leading to ischaemic kidney damage

61
Q

Which blood parameters increase in both AKI and CKD?

A

Urea, creatinine, SDMA & phosphorus

62
Q

How should azotaemia (high urea and creatinine) be interpreted?

A

Check urine SG

High USG → Dehydration likely

Low USG + azotaemia → Intrinsic renal disease (AKI or CKD)

63
Q

How does potassium change in AKI vs CKD?

A

AKI → ↑ Potassium (hyperkalaemia) (due to decreased renal clearance)

CKD → ↓ Potassium (hypokalaemia) (due to polyuria & decreased intake (poor appetite))

64
Q

Why is hypocalcaemia significant in AKI?

A

Key marker for ethylene glycol toxicity, especially in cats

65
Q

What does USG <1.035 in cats or <1.030 in dogs with azotaemia suggest?

A

oor concentrating ability + azotaemia → Renal disease (CKD or AKI)

66
Q

What does USG >1.040 suggest in an azotaemic patient?

A

Non-renal cause of azotaemia, e.g. dehydration

67
Q

What does +ve dipstick for glucose indicate if blood glucose is normal?

A

Possible tubular damage → Consider AKI

68
Q

What should be done if a +ve dipstick for protein is found?

A

Run urine protein:creatinine ratio

Increased levels indicate protein-losing nephropathy or tubular damage

69
Q

What does +ve dipstick for blood suggest?

A

Damage anywhere in urinary tract

70
Q

Describe normal ureters

A

Fibromuscular tubes with peristaltic activity carrying urine from renal pelvis to bladder neck

Retroperitoneal structures for most of their length until they become peritoneal near bladder insertion site

71
Q

What is an ectopic ureter?

A

Ureter that doesn’t insert at correct location in bladder but instead inserts into urethra, vestibule, vagina (females), or ductus deferens (males)

Can be unilateral or bilateral

72
Q

What are the two types of ectopic ureters?

A

Extramural: Directly inserts abnormally

Intramural: Appears to insert at correct site but tunnels along urethral wall & opens distally

73
Q

Which sex is more likely to have clinical problems caused by ectopic ureters and why?

A

Females because they have shorter urethra, making them more prone to incontinence

(Males have longer urethra providing some compensation to maintain continence)

74
Q

What are the clinical signs of ectopic ureters?

A

Can be asymptomatic

Incontinence (esp. female)

Urine scalding, dermatitis & pyoderma in perivulvar region

Increased risk of UTIs due to abnormal ureter position

Risk of ascending infections leading to pyelonephritis

75
Q

What surgical complication can lead to ureteric injury?

A

Spaying, if ureter is accidentally included in ligature for ovarian pedicle or cervical stump

76
Q

What non-surgical event can cause ureteric avulsion or partial tearing?

A

Road Traffic Accidents (RTA)

77
Q

How can urine leakage from a damaged ureter be assessed?

A

Using ultrasound to identify location of fluid accumulation

retroperitoneal fluid if proximal injury

peritoneal fluid if distal injury close to bladder

78
Q

What are the three main types of ureteric obstruction?

A

Intraluminal, Intramural & Extramural

79
Q

What can cause intraluminal ureteric obstruction?

A

Calculi (esp. calcium oxalate in cats)

Blood clots

Inflammatory debris (mucus, inflammatory cells)

80
Q

What can cause intramural ureteric obstruction?

A

Stricture (e.g. fibrosis from previous calculi damage)

Neoplasia (rare)

81
Q

What can cause extramural ureteric obstruction?

A

e.g. post-op complications with ligated ureter

82
Q

Why can unilateral ureteral obstruction be easily missed?

A

Clinical signs are non-specific (e.g. pain) & renal failure signs only appear if >66-75% of nephrons are lost

83
Q

What happens to ureteric pressure in unilateral ureteral obstruction?

A

Increased ureteric pressure proximal to obstruction → Increased renal tubular pressure → Decreased GFR

84
Q

What is the consequence of complete unilateral ureteral obstruction?

A

Hydronephrosis (fluid accumulation in kidney)

Fibrosis (leading to small kidney)

85
Q

What is compensatory hypertrophy in unilateral ureteral obstruction?

A

Normal kidney enlarges (big kidney) to compensate for affected kidney’s loss of function

86
Q

Why are animals with unilateral ureteral obstruction not azotaemic?

A

If second kidney is healthy, it maintains renal function, preventing azotaemia

87
Q

Why is a second ureteral obstruction in “big kidney/little kidney” cats serious and life-threatening?

A

Cat relies on big kidney for renal function, as small kidney is likely non-functional or severely reduced in function

Clinical signs:
- Renal pain
- Azotaemia (signs of renal failure)
- Acute Kidney Injury (AKI)

88
Q

Can the renal function be restored after a second ureteral obstruction?

A

Yes, AKI can be reversible, but only with prompt diagnosis & treatment