5- liver and biliary system Flashcards

1
Q

does bile contain digestive enzymes

A

no but it contains bile acids that help break down fats

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2
Q

is the liver essential for life

A

yes

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3
Q

is the gallbladder essential for life

A

nope

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4
Q

what are the roles of endothelial cells in the liver

A

they line the sinusoids, fenestrated

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5
Q

what do bile acids do

A

help dissolve fats

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6
Q

how and where are bile acids synthesized

A

in the hepatocyte from cholesterol

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7
Q

how does pancreatic lipase work

A

only on surface of lipid droplets, it is water soluble

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8
Q

how does bile acids help pancreatic lipase

A

bile acids emulsify it so that pancreatic lipase can work

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9
Q

what forms micelles

A

bile acids

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10
Q

what are micelles

A

store fatty acids and monoglycerides, unstable

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11
Q

what is the function of micelles

A

holds fatty acids and monoglycerides and releases them to diffuse into enterocytes

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12
Q

what do hepatocytes do

A

produce and secrete bile acids, phospholipids and cholesterol into bile canaliculi with 1ary active transport

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13
Q

what does the gall bladder do

A

stores and concentrates the bile between meals

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14
Q

what is enterohepatic circulation

A

recycling of bile acids

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15
Q

how does enterohepatic circulation work

A
  1. bile released into duodenum
  2. absorbed in ileum into portal circulation
  3. transported back into hepatocytes
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16
Q

how does fibre help lower cholesterol

A

fibre sequester bile acids and prevents reabsorption, so more bile acids must be synthesized from cholesterol

17
Q

how does secretin affect bile duct

A

increases HCO3- secretion by bile duct (and pancrease)

18
Q

how does CCK affect bile duct

A

relaxes sphincter of oddi and releases bile into duodenum

19
Q

what are gall stones

A

when [cholesterol] in bile is too high relative to bile acids

20
Q

what are pigment stones caused by

A

too much hemolysis, which increases pigment concentration and pigments precipitate with Ca++