3-stomach Flashcards

1
Q

is the stomach essential for life

A

no, but yes for a good quality of life

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2
Q

what are the regions of the stomach

A

fundus, body, antrum

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3
Q

what is the fundus

A

top of stomach

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4
Q

what is the body of stomach

A

middle of stomach

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5
Q

what is the antrum

A

bottom of stomach

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6
Q

what does pepsinogen do

A

converted to pepsin, helps digest proteins

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7
Q

what do chief cells secrete

A

pepsinogen

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8
Q

where are chief cells

A

all regions of stomach

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9
Q

what is released by G cells

A

gastrin

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10
Q

where are gastric glands

A

antrum

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11
Q

how does gastrin work

A

stimulates HCl production by parietal cell and GI motility

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12
Q

what do ECL cells release

A

histamine

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13
Q

where are ECL cells

A

all stomach areas, more so in the antrum

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14
Q

what do d cells release

A

somatostatin

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15
Q

what does somatostatin do

A

negative regulator of HCl secretion

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16
Q

where are d cells

A

everywhere in stomach, more in antrum

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17
Q

what does intrinsic factor do

A

critical for B12 absorption in the ileum

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18
Q

where is HCl produced

A

fundus and body

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19
Q

where is mucous, pepsinogen and HCl released

A

fundus and body

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20
Q

where is mucous, pepsinogen and gastrin released

A

antrum

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21
Q

what is the fundus and body made from

A

thin layer of smooth muscle

22
Q

what is the antum made of

A

thick smooth much

23
Q

what does histamine do

A

stimulates HCl production

24
Q

what do parietal cells do

A

secrete HCl and IF

25
what are canaliculus and where found
in parietal cell, they increase surface area to maximize secretion
26
which direction does the K+/H+ pump in parietal cell
H+ into lumen, K+ into cell, actively
27
how is carbonic anhydrase made in stomach
formed from H2O and CO2
28
what does H2CO3 dissociate into parietal cells
H+ (for secreion) and HCO3- (exchanged with cl-)
29
what kind of transport is the Cl-/HCO3- exchanger parietal cells
2 active
30
which direction does the Cl-/HCO3- exchanger go parietal cells
HCO3- out Cl- in
31
what happens to Cl- in the parietal cell
comes in from Cl-/HCO3- exchanger | leaves in leak channel
32
what happens to K+ in parietal cells
comes in from K/H+ pump | leaves in leak channel
33
what happens to HCO3- in parietal cells
leaves into blood, causes alkaline tide
34
what happens do H+ in parietal cells
leaves into lumen, makes it acidic
35
what is the cephalic phase of gastric secretion
excitatory, through vagus
36
what is the gastric phase of gastric secretion
major excitatory phase, gastrin
37
what is the intestinal phase of gastric secretion
inhibitory when fat, acid, hypertonic digestion products are in duodenum
38
what does ACh do to D cells
inhibit release of somatostatin
39
what does somatostatin do to parietal cells
inhibit H+ release
40
what does somatostatin do to ECL cells
inhibit histamine release
41
what does somatostatin do to G cells
inhibit gastrin release
42
what does ACh do to G cells
activate gastrin release
43
what does peptides do to G cells
activate gastrin release
44
what does H+ do to D cells
activate somatostatin release
45
what does H+ do to G cells
inhibit gastrin release
46
what does gastrin do to ECL cells
activate histamine release
47
what does ACh do to ECL cells
activate histamine release
48
where is the pyloric sphincter
at bottom/antrum
49
what do stomach pacemaker cells do
presets the frequency of contractions
50
what closes off in vomiting
glottis
51
what is damaged in ulcers
mucosa (top)