4-pancreas Flashcards
is the pancreas majorily exocrine or endocrine
exocrine
what are the major exocrine secretions
enzymes and HCO3-
what are the major endocrine secretions
hormones (insulin), non-digestive!
what is the main pancreatic duct
join common bile duct just before entering duodenum
what is the tonicity of pancreatic juice
isotoic
what is the acidity of pancreatic juice
alkaline
what is in pancreatic juice
electrolytes and enzymes
who secreted most of the HCO3- and H2O
duct cells
who secretes digestive enzymes
Acinar cells
how is neutral ph conserved in duct cells
H+ goes out as well as HCO3-
what drives water and Na into lumen of duct cells
Cl- leaving the CFTR channel
what is the alkaline tide
parital cells pumping HCO3- into blood
what is the acid tide
pancreatic duct cells secreting H+ into blood
what would happen without the pancreas
starvation!!!
where to acinar cells package pro-enzymes
zymogen granules in the apical pole of the cell
what does enterokinase do
cleaves trypsinogen to trypsin
where is enterokinase
embedded in luminal membrane of duodenum
what happens when the CFTR channel is mutated
HCO3- and H2O secretion is minimal and enzymes do not get flushed from the ducts
what does secretin stimulate
pancreatic and liver cells to increase HCO3- secretion
what does CCK stimulate
release of bile from gall bladder, relax sphincter of oddi
what is the sphincter of oddi
where the pancreatic and bile duct end
what is the cephalic phase of pancreatic secretion
minor phase, sight/smell/taste stimulates secretion via parasympathetic nerve
what is the gastric phase of pancreatic secretion
minor, stomach distention stimulates pancreatic secretion via parasympathetic nerve
what is the intestinal phase of pancreatic secretion
major!! acid in duodenum stimulates secretion, fat and protein in duodenum stimulates CCK
what activates procarboxypeptidase A&B?
trypsin
what activates chymotrypsinogen
trypsin
what activates pro-elastase
trypsin
is procarboxypeptidase A&B an endo or exo peptidase
exopeptidase
is chymotrypsinogen an endo or exo peptidase
endopepsidate
is pro-elastase an endo or exo peptidase
endopeptidase
is trypsinogen an endo or exo peptidase
endopepsidase
what does lipase break down
triglycerides
