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Physiology > 4-pancreas > Flashcards

4-pancreas Flashcards

1
Q

is the pancreas majorily exocrine or endocrine

A

exocrine

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2
Q

what are the major exocrine secretions

A

enzymes and HCO3-

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3
Q

what are the major endocrine secretions

A

hormones (insulin), non-digestive!

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4
Q

what is the main pancreatic duct

A

join common bile duct just before entering duodenum

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5
Q

what is the tonicity of pancreatic juice

A

isotoic

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6
Q

what is the acidity of pancreatic juice

A

alkaline

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7
Q

what is in pancreatic juice

A

electrolytes and enzymes

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8
Q

who secreted most of the HCO3- and H2O

A

duct cells

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9
Q

who secretes digestive enzymes

A

Acinar cells

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10
Q

how is neutral ph conserved in duct cells

A

H+ goes out as well as HCO3-

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11
Q

what drives water and Na into lumen of duct cells

A

Cl- leaving the CFTR channel

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12
Q

what is the alkaline tide

A

parital cells pumping HCO3- into blood

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13
Q

what is the acid tide

A

pancreatic duct cells secreting H+ into blood

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14
Q

what would happen without the pancreas

A

starvation!!!

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15
Q

where to acinar cells package pro-enzymes

A

zymogen granules in the apical pole of the cell

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16
Q

what does enterokinase do

A

cleaves trypsinogen to trypsin

17
Q

where is enterokinase

A

embedded in luminal membrane of duodenum

18
Q

what happens when the CFTR channel is mutated

A

HCO3- and H2O secretion is minimal and enzymes do not get flushed from the ducts

19
Q

what does secretin stimulate

A

pancreatic and liver cells to increase HCO3- secretion

20
Q

what does CCK stimulate

A

release of bile from gall bladder, relax sphincter of oddi

21
Q

what is the sphincter of oddi

A

where the pancreatic and bile duct end

22
Q

what is the cephalic phase of pancreatic secretion

A

minor phase, sight/smell/taste stimulates secretion via parasympathetic nerve

23
Q

what is the gastric phase of pancreatic secretion

A

minor, stomach distention stimulates pancreatic secretion via parasympathetic nerve

24
Q

what is the intestinal phase of pancreatic secretion

A

major!! acid in duodenum stimulates secretion, fat and protein in duodenum stimulates CCK

25
Q

what activates procarboxypeptidase A&B?

A

trypsin

26
Q

what activates chymotrypsinogen

A

trypsin

27
Q

what activates pro-elastase

A

trypsin

28
Q

is procarboxypeptidase A&B an endo or exo peptidase

A

exopeptidase

29
Q

is chymotrypsinogen an endo or exo peptidase

A

endopepsidate

30
Q

is pro-elastase an endo or exo peptidase

A

endopeptidase

31
Q

is trypsinogen an endo or exo peptidase

A

endopepsidase

32
Q

what does lipase break down

A

triglycerides

Physiology (32 decks)

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