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GI and Nutrition > 3.3.2 Pathology of Liver Injury II > Flashcards

3.3.2 Pathology of Liver Injury II Flashcards

1
Q

What are these? What are they found in?

A

Microabcesses; CMV hepatitis

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2
Q

Condition?

A

Chronic Hep

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3
Q

Describe the type of virus, viral family, route of transmission, mean incubation period, frequency of chronic liver dz, diagnosis of the subtypes of standard hepatitis.

A
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4
Q

These are used to measure severity of what?

A

Chronic Hep C

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5
Q

When is CMV hepatitis most common?

A

After renal and liver transplant (immunocompromised)

Must screen for CMV

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6
Q

Condition?

A

Acute Hepatitis

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7
Q

What condition?

A

Chronic Hep B

(Ground Glass Appearance)

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8
Q

What are these? what are they found in?

A

“owl eye” inclusions; CMV hepatitis

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9
Q

Type of Hep?

A

Hep C

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10
Q

What is antigen targeted in the hep B vaccine?

A

HBsAg (surface antigen)

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11
Q

Three conditions that result from non-alcoholic fatty liver dz?

A

steatosis, steatohepatitis, fibrosis

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12
Q

Condition?

A

Alcohol-induced liver dz

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13
Q

Condition?

A

Alcoholic hepatitis

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14
Q

Type of Hep?

A

Hep D

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15
Q

What is the end stage outcome of chronic hepatitis?

A

Cirrhosis

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16
Q

What are the diagnostic criteria for autoimmune hepatitis?

A
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17
Q

What are the clinical signs of cirrhosis?

A
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18
Q

What is the abundant cell type? Condition?

A

Plasma Cell; AI hepatitis

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19
Q

Condition?

A

Hepatic steatosis

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20
Q

Condition?

A

Non-alcoholic fatty liver dz

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21
Q

Condition?

A

Autoimmune hepatitis

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22
Q

What are the four different presentations of hepatitis?

A
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23
Q

What is the common result of acute hep? chronic hep? fulminant hep?

A
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24
Q

What type of hepatitis?

25
Q

What type of patients are commonly affected by herpes hepatitis?

A

Immunocompromised pts

26
Q

What are the three conditions caused by alcohol-induced liver dz?

A

Steatosis, hepatitis, cirrhosis

27
Q

What are the 3 M’s of herpes hepatitis?

A

Multinucleation, Molding, Margination

28
Q

Where are the dominant features in acute viral hepatitis?

A

Lobular/acinus

29
Q

Type of Hep?

30
Q

What are some of the features of the two stages of autoimmune hepatitis?

31
Q

What is seen on biopsy of CMV hepatitis?

A

Focal hepatocyte necrosis, microabcesses, and ocasssional sinusoidal lymphocytic infiltrate, “owl’s eye” intranuclear inclusion

32
Q

Condition?

A

Alcoholic hepatitis

33
Q

Persitant inflammatory reaction of the liver with more than 6 months of clinical signs and symptoms?

A

Chronic hep

34
Q

What dz process is shown below?

A

Confluent necrosis

35
Q

What is used to treat/reduce inflammation in AI hepatitis?

36
Q

Type of Hep?

37
Q

This the dream treatment for chronic hep C. What is it?

38
Q

Type of Hep?

39
Q

What dz process is shown below?

A

Interface Hep

40
Q

Left? Right?

A

Left: Acute hep

Right: Normal

41
Q

Type of Hep?

42
Q

Condition?

A

Alcohol-induced liver dz

43
Q

What dz process is shown below?

A

Apoptosis and lobular inflammation

44
Q

Condition?

A

Acetominophen OD

45
Q

Which types of acute hepatitis commonly progress to chronic?

46
Q

Condition?

A

Hepatic Steatosis

47
Q

What dz process is shown below?

A

Interface inflammation

48
Q

Can affect both immunocompetent and immunocompromised patients. Causes diffuse sinusoidal lymphocytic infiltrate “string of pearls” with varying degrees of portal inflammation.

A

EBV hepatitis

49
Q

What are some of the histologic characteristics of hepatic herpes?

A

Patchy coagulative necrosis, no particular zonal distribution

Eosinophilic intranuclear inclusions

50
Q

This type of hepatitis: Vaccine; no carrier or chronic state; spread through fecal-oral contamination; endemic in countries with substandard sanitation; sporadic, febrile illness with jaundice fatigue, loss of appetite

51
Q

What dz process is shown below?

A

Portal inflammation

52
Q

Symptoms and clinical presentation of fulminant hep.

53
Q

Condition?

A

Fulminant Hep

54
Q

What type of cell is increased in AI hepatitis?

A

Plasma cells

55
Q

Condition?

A

Chronic Hep C

56
Q

Type of Hep?

57
Q

What some of the viral cause of hepatitis?

A

EBV, CMV, Yellow fever, Herpes, Hepatic viruses A, B, C, D, E

58
Q

What accounts for 30% of transplants in US?

A

Chronic hep C

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