3.1.1+2 Protective Mechanisms, Inflammatory Bowel Dz (IBD), Irritable Bowel Syndrome (IBS) Flashcards
A functional disorder absent of histologic and radiologic findings?
IBS, irritable bowel syndrome
What typically cures UC?
Removal of colon
What are some surgical indications in UC?
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What the three biolgic therapies used in the treatment of IBD? What do they target?
Infliximab (remicade), certolizumab (cimzia), adalimumab (humira); TNF-alpha
What dis b? What is it often associated with?
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Pseudomembranous colitis; C. Diff infection
IBD increases the risk of what type of cancer?
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Colorectal cancer
Fill Dis Out, yo
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Chron is thicka than a sticka
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What are the three dz’s included in IBD?
UC, Chron’s Dz, Indeterminate Colitis
What is the role of the defensins released by paneth cells?
Help defend against food and water borne pathogens
What is one of the diseases associated with chron dz?
Perianal Dz
![](https://s3.amazonaws.com/brainscape-prod/system/cm/209/578/681/a_image_thumb.png?1490020369)
What three factors must be considered when choosing a medical therapy?
Dz distribution, dz severity, prior therapy
What is not present histologically in UC that can be present in Chron?
Granulomas
What % of patients experience a clinical response to biologics? % of remission?
60% response, 30% remission
Inflammation, fibrosis of biliary tree
(assoicated w/ cholangiocarcinoma)
Primary Sclerosing Cholangitis; course of dz is independent of course of UC
What type of dz are biologics particularly useful for?
Fistulizing dz in CD
What is the pathology of Chrons? How often are granulomas present?
Transmural (entire wall) inflammation with neutrophilic abcesses (crypt abscesses, architectural distortion)
15-50%
How might the gut flora be altered in IBS?
Reduced: lactobacilli and bifidobacterium
Increased: clostridium
Describe the positive/negative balance that exists in the GI system.
Negative: Bad flora, Inflammation, NF-kB, infection
Positive: Good flora, mucus, barrier function, IgA, defensins, B cells, T cells, NF-kB, Acid, Motility, Cell turnover
What are some of the symptoms associated with the different severities associated with UC?
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What is the typical onset pattern of UC?
Slow and insidious (symptom onset to diagnosis is typically 9 months)
What are the three complications of IBD?
toxic megacolon, primary sclerosing cholangitis, colon cancer
What are the four different classes of medical therapies for IBD? Their ideal usage?
Aminosalicylates (less severe dz cases), GCs (induce remission, not as good for maintaining), Immunomodulators (maintenance of remission); Biologics (induction/maintanence of remission)
Defined as dilation of the colon with fulminant (severe and sudden onset) colitis
Toxic megacolon
Where are certain bacteria located along the GI tract? (vaguely know)
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