3/2 Flashcards
Type of collagen in:
Dermis, bone, tendons, ligaments, dentin, cornea, blood vessels, scar tissue?
Type 1
Associated disease is osteogenesis imperfecta, get blue sclera
Type of collagen in: cartilage, vitreious humor, nucleus pulposus?
Type 2
Type of collagen in:
Skin, lungs, intestines, blood vessels, bone marrow, lymphatics, granulation tissue?
Type 3 (Associated disease is Ehlers Danlos syndrome, types 3 and 4)
Type of collagen in:
Basement membranes?
Type 4 (Associated diseases are Ehlers Danlos syndrome, types 3 and 4, and Alport syndrome)
Where would you find type 1 collagen?
Dermis, bone, tendons, ligaments, dentin, corneas, blood vessels, scar tissue
Where would you find type 2 collagen?
Cartilage, vitreous humor, nucleus pulposus
Where would you find type 3 collagen?
Skin, lungs, intestines, blood vessels, bone marrow, lymphatics, granulation tissue
Where would you find type 4 collagen?
Basement membranes
What is the primary finding in Kartagener syndrome, and what symptoms result?
Immotile cilia from an AR mutation in dynein gene.
Sx include male infertility, recurrent sinusitis, bronchiectasis.
Can see situs inversus!
What LDL lowering drug class results in hypertriglyceridemia?
Bile acid-binding resin
Cholestyramine, colestipol, colesevelam
Also cause GI upset, impaired nutrient and drug absorption, and increased risk for cholesterol gallstones
What color are cavernous hemangiomas?
Blue, soft, compressible masses up to a few cm
What nephropathy is described by a diffuse increased thickness of glomerular basement membrane on light microscopy without increased cellularity, with spike and dome appearance on silver stain and granular deposits on immunofluorescence?
Membranous glomerulopathy
HIV pol gene mutations lead to what sort of HAART resistance?
Mutated HIV-1 reverse transcriptase are resistant to NRTIs and NNRTIs
To what areas of the hand does the ulnar nerve provide sensory innervation?
5th digit, medial 4th digit, palmar and dorsal surfaces
Where are the different CK isoforms found?
CK-MB
CK-BB
CK-MM
CK-MB: cardiac muscle
CK-BB: nervous system
CK-MM: skeletal muscle
Primary tx for acute mania?
Mood stabilizer
Lithium, valproate, carbamazepine
Monotherapy effective in 60%, can be used with atypical antipsychotic (e.g. olanzapine)
Facial nerve functions?
- Motor output to facial muscles
- PS innervation to salivary glands (except parotid), and lacrimal
- Taste for anterior 2/3 of tongue
- Somatic sensation from pinna and external auditory canal
Reed Sternberg cells look like what? What do they indicate?
Ample cytoplasm, bilobed/double nuclei, inclusion like nucleoli:
Hodgkin’s disease!
What is the characteristic histologic finding for Burkitt’s lymphoma?
Starry sky
