Zopiclone

Question 1

absorption

Answer 1

rapidly absorbed with bioavailability of 80%

Question 2

distribution

Answer 2

rapidly and widely distributed to body tissues

Question 3

metabolism

Answer 3

partly metabolised in liver forming an inactive N demethylated derivative and an active N oxide metabolite

Question 4

excretion

Answer 4

excreted in urine, saliva and breast milk

Question 5

MOA

Answer 5

1. novel hypnotic agent
2. works by modulating benzodiazepine receptors
3. increases activity of the neurotransmitter GABA which results in an increased inhibitory effect that slows the firing of other neurotransmitters

Question 6

indications

Answer 6

1. insomnia

Question 7

adverse effects

Answer 7

• bitter taste
• anxiety

Question 8

interactions

Answer 8

• carbamazepine
• verapamil

Question 9

contraindications

Answer 9

• marked neuromuscular respiratory weakness
• respiratory failure
• severe sleep apnoea syndrome