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OSCE Drug formulary > Carbamazepine > Flashcards

Carbamazepine Flashcards

1
Q

absorption

A

slowly but completely absorbed

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2
Q

distribution

A

70% bound to plasma proteins

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3
Q

metabolism

A

mainly hepatic by CYP450 2D6 and 3A4

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4
Q

excretion

A

excreted in urine

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5
Q

MOA

A
  1. GABA agonist
  2. works by reducing neuronal excitability and enhancing inhibition of Na+, K+ OR Ca through the GABA and glutamate neurotransmitters
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6
Q

indications

A
  1. focal and secondary generalised tonic clonic seizures
  2. prophylaxis of bipolar disorder unresponsive to lithium
  3. diabetic neuropathy
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7
Q

adverse effects

A
  • dizziness/drowsiness
  • fluid imbalance
  • oedema
    thrombocytopaenia
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8
Q

interactions

A
  • lithium
  • warfarin
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9
Q

contraindications

A
  • AV conduction abnormalities
  • history of bone marrow depression
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OSCE Drug formulary (29 decks)

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