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OSCE Drug formulary > Haloperidol > Flashcards

Haloperidol Flashcards

1
Q

absorption

A

low bioavailability due to first pass metabolism but well absorbed from GIT

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2
Q

distribution

A

high volume of distribution as it is highly lipophilic

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3
Q

metabolism

A

extensively metabolised in liver and is biotransformed to several metabolites by oxidative N dealkylation

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4
Q

excretion

A

renally in faeces and urine

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5
Q

MOA

A
  1. works by competitive blocking the post synaptic dopamine receptor in the brain
  2. this eliminates dopamine neurotransmission which helps with symptoms of delusions and hallucinations
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6
Q

indications

A
  1. prophylaxis of postoperative nausea and vomiting
  2. schizophrenia
  3. moderate to severe manic episodes associated with bipolar disorder
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7
Q

adverse effects

A
  • depression
  • Extrapyrimidal side effects (dystonia)
  • hyperprolactinaemia
  • weight decrease
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8
Q

interactions

A
  • fingolimod
  • furosemide
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9
Q

contraindications

A
  • CNS depression
  • heart failure
  • uncorrected hypokalaemia
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OSCE Drug formulary (29 decks)

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