Warfarin Flashcards
1
Q
absorption
A
completely absorbed following administration
2
Q
distribution
A
has a small volume of distribution because it binds extensively to plasma proteins
3
Q
metabolism
A
hepatic metabolism through CYP450 system
4
Q
excretion
A
renal excretion by glomerular filtration
5
Q
MOA
A
- vitamin K antagonist
- works by competitively inhibiting the vitamin K epoxide reductase complex which is essential for activating vitamin K available in body
- leads to depletion of functional vitamin K reserves
- reduces synthesis of active clotting factors
6
Q
indications
A
- prophylaxis of embolisation in heart disease and AF
- Treatment of venous thrombosis and pulmonary embolism
7
Q
adverse effects
A
- haemmorhage
- abnormal hepatic function
8
Q
interactions
A
- aspirin
- enoxaparin
9
Q
contraindications
A
- avoid use within 48 hours postpartum
- haemorrhagic stroke
- significant bleeding