Spironolactone

Question 1

absorption

Answer 1

bioavailability increases with food

Question 2

distribution

Answer 2

highly protein bound

Question 3

metabolism

Answer 3

deacetylated to 7-thiospironolactone and eventually to canrenone through an elimination reaction

Question 4

excretion

Answer 4

mainly excreted in urine and faeces

Question 5

MOA

Answer 5

1. an aldosterone receptor antagonist
2. works by competitively inhibiting aldosterone dependent sodium potassium exchange channels in the distal convoluted tubule
3. leads to increased water and sodium excretion and more potassium retention

Question 6

indications

Answer 6

1. oedema
2. moderate to severe heart failure

Question 7

adverse effects

Answer 7

• acute kidney injury
• electrolyte imbalance
• agranulocytosis

Question 8

interactions

Answer 8

abiraterone

Question 9

contraindications

Answer 9

• Addisons disease
• hyperkalaemia