Insulin Glargine

Question 1

absorption

Answer 1

has an absorption period of about 24 hours as small amounts are slowly released

Question 2

metabolism

Answer 2

hepatic metabolism into 2 active metabolites, M1 and M2

Question 3

MOA

Answer 3

1. binds to insulin receptor
2. stimulates tyrosine kinase activity
3. leading to activation of downstream signalling molecules

Question 4

indications

Answer 4

1. diabetes mellitus

Question 5

adverse effects

Answer 5

• oedema
• taste altered
• overdose causes hypoglycaemia

Question 6

interactions

Answer 6

• clarithromycin

Question 7

contraindications

Answer 7

• insulin requirements should be assessed during pregnancy and breastfeeding
• dose reduction may be necessary in hepatic impairment