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OSCE Drug formulary > Quetiapine > Flashcards

Quetiapine Flashcards

1
Q

absorption

A

rapidly absorbed

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2
Q

distribution

A

widely distributed and 83% bound to plasma proteins

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3
Q

metabolism

A

extensively metabolised by liver by oxidation and by CYP3A4

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4
Q

excretion

A

hepatic metabolism

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5
Q

MOA

A
  1. a dopamine D1, dopamine D2, 5HT, alpha 1 adrenoceptor and muscarinic receptor antagonist
  2. blocks the 5HT serotonin receptors and dopamine receptors
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6
Q

indications

A
  1. schizophrenia
  2. treatment of mania in bipolar disorder
  3. treatment of depression in bipolar disorder
  4. adjunctive treatment of major depression
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7
Q

adverse effects

A
  • palpitations
  • peripheral oedema
  • sleep disorders
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8
Q

interactions

A
  • grapefruit
  • lithium
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9
Q

contraindications

A
  • CV disease
  • epilepsy
  • diabetes
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OSCE Drug formulary (29 decks)

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