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OSCE Drug formulary > Amitryptilline > Flashcards

Amitryptilline Flashcards

1
Q

absorption

A

slowly and completely absorbed from GIT

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2
Q

DISTRIBUTION

A

mainly distributed in plasma

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3
Q

metabolism

A

hepatic by CYP2C19 and CYP2D6 pathways

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4
Q

excretion

A

mainly excreted by urine

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5
Q

MOA

A
  1. tricyclic antidepressant
  2. increases noradrenergic or serotonergic neurotransmission by blocking NET or SERT at presynaptic terminals
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6
Q

therapeutic indications

A
  1. abdominal pain or discomfort
  2. major depressive disorder
  3. neuropathic pain
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7
Q

adverse effects

A
  • anticholinergic syndrome
  • drowsiness
  • QT interval prolongation
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8
Q

interactions

A

clozapine
lithium

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9
Q

contraindications

A

-arrhythmias
- during manic phase of bipolar disorder
- avoid in severe hepatic impairment

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OSCE Drug formulary (29 decks)

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