Diazepam

Question 1

absorption

Answer 1

rapidly and completely absorbed from GIT

Question 2

distribution

Answer 2

widely distributed throughout body and can penetrate BBB and placental barriers

Question 3

metabolism

Answer 3

hepatic by CYP2C19 and CYP3A4 to its major active metabolite, desmethyldiazepam

Question 4

excretion

Answer 4

renal excretion, mainly in urine

Question 5

MOA

Answer 5

1. benzodiazepine
2. works by binding at specific receptors at several sites in the CNS
3. causing dose related CNS depressant activity
4. enhances GABA receptor function and binds at an allosteric site

Question 6

indications

Answer 6

1. muscle spasms
2. anxiety
3. insomnia associated with anxiety

Question 7

adverse effects

Answer 7

• abnormal appetite
• impaired concentration
• GI disorders

Question 8

interactions

Answer 8

• phenytoin

Question 9

contraindications

Answer 9

• CNS depression
• respiratory depression
• sleep apnoea syndrome