prednisolone

Question 1

absorption

Answer 1

rapidly absorbed in GIT

Question 2

metabolism

Answer 2

hepatic by CYP450 enzymes

Question 3

excretion

Answer 3

metabolites excreted in bile and urine

Question 4

MOA

Answer 4

1. corticosteroid
2. works by exerting glucocorticoid effects and minimal mineralocorticoid effects
3. decreases inflammation by decreasing vasodilation and permeability of the capillaries
4. decreased leukocyte migration to sites of inflammation

Question 5

indications

Answer 5

1. acute exacerbation of COPD
2. mild to moderate acute asthma, life threatening asthma
3. local treatment of inflammation
4. crohns disease

Question 6

adverse effects

Answer 6

• local reaction
• cognitive impairment
• electrolyte imbalance

Question 7

interactions

Answer 7

• digoxin
• lithium

Question 8

contraindications

Answer 8

• avoid alone in presence of untreated infection
• avoid live virus vaccines in those receiving immunosuppressive doses