Azathioprine Flashcards
1
Q
absorption
A
readily absorbed from GIT
2
Q
distribution
A
30% bound to proteins such as serum albumin
3
Q
metabolism
A
hepatic
- converted to 6-mercaptopurine
4
Q
excretion
A
renal excretion
5
Q
MOA
A
- inhibits purine synthesis which is needed to produce RNA and DNA
- this means a smaller amount of DNA and RNA are produced
- leading to immunosuppression
6
Q
therapeutic indications
A
- severe crowns disease
- rheumatoid arthritis that hasn’t responded to disease modifying drugs
- suppression of transplant rejection
7
Q
adverse effects
A
- bone marrow depression
- increased risk of infection
- thrombocytopaenia
8
Q
interactions
A
- MMR vaccine
- ramipril
9
Q
contraindications
A
- reduced dose in elderly
- very low thiopurine methyltransferase activity
