Clozapine

Question 1

absorption

Answer 1

bioavailability 60-70% due to first pass metabolism
- almost completely absorbed after administration

Question 2

distribution

Answer 2

97% bound to plasma proteins

Question 3

metabolism

Answer 3

hepatic by CYP450 enzymes through demethylation and oxidation

Question 4

excretion

Answer 4

excreted in urine and faeces

Question 5

MOA

Answer 5

1. a dopamine D1, dopamine D2, 5HT, alpha 1 adrenoceptor and muscarinic receptor antagonist
2. blocks the 5HT serotonin receptors and dopamine receptors

Question 6

indications

Answer 6

1. schizophrenia in patients unresponsive to conventional antipsychotic drugs
2. psychosis in parkinsons disease

Question 7

adverse effects

Answer 7

• decreased apetite
• speech impairment
• fever

Question 8

interactions

Answer 8

• carbamazepine
• buprenorphine

Question 9

contraindications

Answer 9

• bone marrow disorders
• severe CNS depression
• uncontrolled epilepsy