Lithium Flashcards
1
Q
absorption
A
rapidly absorbed from GIT
2
Q
distribution
A
not protein bound and has a small volume of distribution
3
Q
metabolism
A
not metabolised by the liver
4
Q
excretion
A
renal excretion, unchanged in urine
5
Q
MOA
A
- works by reducing excitatory neurotransmission
- dopamine and glutamate - increases inhibitory neurotransmission
- GABA
6
Q
indications
A
- treatment of mania, bipolar disorder, recurrent depression, aggressive or self harming behaviour
7
Q
adverse effects
A
increased thirst
fatigue
weight gain
metallic taste
8
Q
what are the signs of overdose
A
- vomiting and diarrhoea
- visual disturbances
- tremor
9
Q
interactions
A
ibuprofen
verapamil
10
Q
contraindications
A
- Addisons disease
- cardiac disease associated with rhythm disorder
- dehydration
- low sodium diet
