citalopram Flashcards
1
Q
absorption
A
rapidly absorbed from GIT
- bioavailability of 80%
2
Q
distribution
A
widely distributed as its highly lipophilic
- but its metabolite doesn’t penetrate BBB well
3
Q
metabolism
A
mainly hepatic via demethylation by CYP3A4
4
Q
excretion
A
renally via urine and faeces
5
Q
MOA
A
- selective seratonin reuptake inhibitor
- selectively inhibits reuptake of serotonin
6
Q
indications
A
- depressive illness
- panic disorder
7
Q
adverse effects
A
- abnormal apetite
- acute angle closure glaucoma
- migraine
8
Q
interactions
A
- enoxaparin
- amiodarone
9
Q
contraindication
A
- poorly controlled epilepsy
- main phase
- QT interval prolongation
