Temazepam Flashcards
1
Q
absorption
A
very well absorbed
2
Q
distribution
A
highly bound to plasma proteins
3
Q
metabolism
A
hepatic metabolism to inactive metabolites
4
Q
excretion
A
mainly urine and faeces
5
Q
MOA
A
- benzodiazepine
- works by binding at specific receptors at several sites in the CNS
- causing dose related CNS depressant activity
- enhances GABA receptor function and binds at an allosteric site
6
Q
indications
A
- insomnia
- conscious sedation for dental procedures
- premedication before surgery
7
Q
adverse effects
A
- slurred speech
- confusion
- hypersalivation
8
Q
interactions
A
- quetiapine
- methadone
9
Q
contraindications
A
-CNS depression
- respiratory depression
