Sodium Valproate

Question 1

absorption

Answer 1

rapidly absorbed from GIT

Question 2

distribution

Answer 2

small volume of distribution and is largely bound by plasma proteins

Question 3

metabolism

Answer 3

hepatic metabolism by CYP450

Question 4

Excretion

Answer 4

excreted in urine

Question 5

MOA

Answer 5

1. works by acting on GABA levels in the CNS and blocking voltage gated ion channels
2. it increases amount of GABA in the brain which blocks transmission across nerves in the brain

Question 6

indications

Answer 6

1. all forms of epilepsy
2. migraine prophylaxis

Question 7

adverse effects

Answer 7

• abdominal pain
• anaemia
• concentration impaired

Question 8

interactions

Answer 8

• phenytoin

Question 9

contraindications

Answer 9

• known or suspected mitochondrial disorders
• history of severe hepatic dysfunction