methadone Flashcards
1
Q
absorption
A
absorbed in stomach with a 75% bioavailability
2
Q
distribution
A
highly distributed and highly plasma protein bound
3
Q
metabolism
A
extensive first pass metabolism involving CYP3A4 and undergoes demethylation
4
Q
excretion
A
renally in urine and faeces
5
Q
MOA
A
- an opioid analgesic that has agonist activity at the Mu opioid receptor
- also acts on K and delta opioid receptors as an agonist
6
Q
indications
A
- severe pain
- adjunct in treatment of opioid dependence
- cough in palliative care
7
Q
adverse effects
A
- asthma exacerbation
- constipation
- euphoric mood
8
Q
interactions
A
- buprenorphine
- phenytoin
9
Q
contraindications
A
-acute respiratory depression
- head injury
- raised intracranial pressure
