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OSCE Drug formulary > diltiazem > Flashcards

diltiazem Flashcards

1
Q

absorption

A

readily absorbed from GIT

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2
Q

Distribution

A

70% bound to plasma proteins

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3
Q

metabolism

A

undergoes extensive first pass metabolism, so low bioavailability
- undergoes demethylation by CYP3A4 and CYP2D6

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4
Q

excretion

A

renally excreted

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5
Q

MOA

A
  1. calcium channel blocker
  2. interferes with the inward displacement of calcium ions
  3. have an effect on myocardial cells and vascular smooth muscle cells
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6
Q

indications

A
  1. prophylaxis and treatment of angina
  2. mild to moderate hypertension
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7
Q

adverse effects

A
  • constipation
  • peripheral oedema
  • flushing
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8
Q

interactions

A
  • bisoprolol
  • digoxin
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9
Q

contraindications

A
  • cardiogenic shock
  • heart failure
  • severe bradycardia
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OSCE Drug formulary (29 decks)

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