enoxaparin

Question 1

absorption

Answer 1

mean absolute bioavailability given sc is approx 100%

Question 2

distribution

Answer 2

volume of distribution of 4-5L

Question 3

metabolism

Answer 3

hepatic by depolymerisation to lower and less potent molecular weight metabolites

Question 4

excretion

Answer 4

mainly renal excretion

Question 5

MOA

Answer 5

1. low molecular weight heparin
2. works by accelerating the rate of neutralisation of certain activated coagulation factors by antithrombin and by blocking the body natural clotting factors

Question 6

indications

Answer 6

1. treatment of venous thromboembolism in pregnancy
2. prophylaxis of deep vein thrombosis
3. treatment of acute ST segment elevation myocardial infarction

Question 7

adverse effects

Answer 7

• haemorrhagic anaemia
• hypersensitivity
• thrombocytopaenia

Question 8

interactions

Answer 8

• ibuprofen
• aspirin
• rivaroxiban

Question 9

contraindications

Answer 9

• mechanical prosthetic heart valve
• after major trauma
• recent eye surgery