Rivaroxaban

Question 1

absorption

Answer 1

rapidly absorbed, bioavailability increases with food

Question 2

distribution

Answer 2

high plasma protein binding

Question 3

metabolism

Answer 3

metabolised in liver by CYP3A4

Question 4

excretion

Answer 4

renally excreted

Question 5

MOA

Answer 5

1. direct inhibitor of activated factor X
2. inhibits free and clot bound factor Xa which is needed too activate prothrombin to thrombin

Question 6

indications

Answer 6

1. prophylaxis of venous thromboembolism following knee or hip replacement surgery
2. treatment of deep vein thrombosis, pulmonary embolism

Question 7

adverse effects

Answer 7

• anaemia
• haemorrhage
• oedema
• hypotension

Question 8

interactions

Answer 8

• enoxaparin
• warfarin

Question 9

contraindications

Answer 9

• active bleeding
• previous stroke
• use with any other anticoagulant