methotrexate Flashcards
1
Q
absorption
A
generally completely absorbed
2
Q
distribution
A
widely distributed into body tissues and approx 50% protein bound
- highest concentrations found in kidneys, gallbladder, liver
3
Q
metabolism
A
hepatic metabolism to methotrexate polyglutamate
4
Q
excretion
A
mainly renally as intact drug
5
Q
MOA
A
- inhibits dihydrofolate reductase
- which is necessary for synthesis of purines and pyrimidines
6
Q
indications
A
- severe crohns disease
- moderate to severe active rheumatoid arthritis
- severe psoriasis unresponsive to conventional therapy
7
Q
adverse effects
A
- anaemia
- decreased appetite
- increased risk of infection
8
Q
interactions
A
- aspirin
- ibuprofen
9
Q
contraindications
A
- active infection
- immunodeficiency syndromes
