Vulvar and Cervical Cancer 1 Flashcards
Define the criteria that make the pap smear a successful screening tool for cervical cancer.
1
Q
What are some important features of the HPV virus? DNA or RNA? Enveloped?
A
- Circular dsDNA
- 8kbp, 8-9 ORF
- Non-enveloped
- Icosahedral capsid
2
Q
What are the criteria that make the pap smear a succsessful tool for cervical cancer?
A
- Liquid-based
- sensitivity > 95%
- allows for reflex testing
- HPV
- gonorrhea
- chlamydia
3
Q
What doe the following terms mean? NILM, ASC-US, LSIL, HSIL, ASC-H, AGC?
A
- NILM = No INtraepithelial Lesions or Malignancy
- ASC-US = Atypical Squamous Cells of Unknown Significance
- LSIL = Low-Grade Squamous Intraepithelial Neoplasia
- HSIL = High-Grade Squamous Intraepithelial Neoplasia
- ASC-H = Atypical Squamous Cells-Cannot exclude High-Grade Lesion
- AGC = Atypical Glandular Cells
4
Q
What is the use of HPV testing?
A
- Compared to cytology
- greater sensitivity for CIN2,3
- better reproducibility
- Diagnostic uses
- triage of ASCUS Pap
- triage of menopausal LGSIL
- post-treatment screening
- most clear HPV >/= 6 months LEEP
-
Co-testing - HPV testing plus cytology
- increased detection of CIN 3
- similar Cx CA rates testing Q5 yrs vs. to cytology alone Q3 yrs
- enhances detection of adenocarcinoma