Vulvar and Cervical Cancer 1 Flashcards

Define the criteria that make the pap smear a successful screening tool for cervical cancer.

1
Q

What are some important features of the HPV virus? DNA or RNA? Enveloped?

A
  • Circular dsDNA
  • 8kbp, 8-9 ORF
  • Non-enveloped
  • Icosahedral capsid
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2
Q

What are the criteria that make the pap smear a succsessful tool for cervical cancer?

A
  • Liquid-based
    • sensitivity > 95%
    • allows for reflex testing
      • HPV
      • gonorrhea
      • chlamydia
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3
Q

What doe the following terms mean? NILM, ASC-US, LSIL, HSIL, ASC-H, AGC?

A
  • NILM = No INtraepithelial Lesions or Malignancy
  • ASC-US = Atypical Squamous Cells of Unknown Significance
  • LSIL = Low-Grade Squamous Intraepithelial Neoplasia
  • HSIL = High-Grade Squamous Intraepithelial Neoplasia
  • ASC-H = Atypical Squamous Cells-Cannot exclude High-Grade Lesion
  • AGC = Atypical Glandular Cells
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4
Q

What is the use of HPV testing?

A
  • Compared to cytology
    • greater sensitivity for CIN2,3
    • better reproducibility
  • Diagnostic uses
    • triage of ASCUS Pap
    • triage of menopausal LGSIL
    • post-treatment screening
      • most clear HPV >/= 6 months LEEP
  • Co-testing - HPV testing plus cytology
    • increased detection of CIN 3
    • similar Cx CA rates testing Q5 yrs vs. to cytology alone Q3 yrs
    • enhances detection of adenocarcinoma
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