Endocrine Control Female Reproduction 5 Flashcards

Explain the estradiol feedback on gonadotropin secretion.

1
Q

How do the sex hormones negatively and positively feed back on the pituitary?

A
  • Negative feedback
    • E2 and P slow GnRH pulse frequency
  • Positive feedback
    • E2 increases pituitary GnRH receptors and sensitivity to GnRH
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2
Q

Why is E2 positive feedback necessary?

A
  • necessary for LH surge and ovulation
    • depends on amount and duration of E2 secretion
  • LH surge stimulates ovulation of mature follicle and progesterone production by the corpus luteum
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