Uterine Pathology 1 Flashcards
Describe the range of histologic changes of endometrium in different hormonal status.
1
Q
Describe the histologic features of proliferative endometrium.
A
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Proliferative EM
- tubular glands that become increasingly coiled during the proliferative phase
- glands and stromal ratio: low
- polarity of basal and superficial glands, and vessels
- pseudostratified elongated, mitotically active nuclei
- “pencil thin” nuclei
- stromal cells with scant, indistinct cytoplasm
- small round and cellular stromal cells with frequent mitosis
2
Q
Describe the histologic features of the endometrium during the early secretory endometrium.
A
- The secretory phase is the easiest to date based on histology
- Subnuclear vacuoles supranuclear vacuoles
- Secretion starts as vacuoles disappear
- Stroma similar to proliferative phase with edema
- Mitosis evident
3
Q
Describe the histologic features of the endometrium during the mid secretory endometrium.
A
- Maximal stromal edema
- Maximal glandular secretion
- Day 22 tortuous glands
4
Q
Describe the histologic features of the endometrium during the late secretory phase.
A
- Stromal decidualization
- decidualization begins around spiral arteries
- then under surface mucosa
- finally, the entire endometrium
- Diffuse stromal luteinization and spotting granular cells
5
Q
What are the histologic features of the menstrual endometrium?
A
- Exhausted secretory glands
- Hemorrhage and fibrin
- Stromal collapse
- Acute inflammation
6
Q
What are the histologic features of atrophic endometrium?
A
- Common cause of post-menopause bleeding
- Lack of estrogen support
- Thin layer of atrophic glands and stroma