Uterine Pathology 1 Flashcards

Describe the range of histologic changes of endometrium in different hormonal status.

1
Q

Describe the histologic features of proliferative endometrium.

A
  • Proliferative EM
    • tubular glands that become increasingly coiled during the proliferative phase
    • glands and stromal ratio: low
    • polarity of basal and superficial glands, and vessels
    • pseudostratified elongated, mitotically active nuclei
      • “pencil thin” nuclei
    • stromal cells with scant, indistinct cytoplasm
    • small round and cellular stromal cells with frequent mitosis
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2
Q

Describe the histologic features of the endometrium during the early secretory endometrium.

A
  • The secretory phase is the easiest to date based on histology
  • Subnuclear vacuoles supranuclear vacuoles
  • Secretion starts as vacuoles disappear
  • Stroma similar to proliferative phase with edema
  • Mitosis evident
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3
Q

Describe the histologic features of the endometrium during the mid secretory endometrium.

A
  • Maximal stromal edema
  • Maximal glandular secretion
  • Day 22 tortuous glands
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4
Q

Describe the histologic features of the endometrium during the late secretory phase.

A
  • Stromal decidualization
    • decidualization begins around spiral arteries
    • then under surface mucosa
    • finally, the entire endometrium
  • Diffuse stromal luteinization and spotting granular cells
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5
Q

What are the histologic features of the menstrual endometrium?

A
  • Exhausted secretory glands
  • Hemorrhage and fibrin
  • Stromal collapse
  • Acute inflammation
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6
Q

What are the histologic features of atrophic endometrium?

A
  • Common cause of post-menopause bleeding
  • Lack of estrogen support
  • Thin layer of atrophic glands and stroma
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