Gestational Trophoblastic Disease 2 Flashcards

Describe the genetics of hydatidiform moles.

1
Q

What are the types of hydatidiform moles? What are the genetics?

A
  • Monospermic CHM = 46XX
    • loss of maternal chromosomes
    • duplication of paternal chromosomes
  • Dispermic CHM = 46XX or 46XY
  • Diploid biparental CHM = 46XX or 46XY
    • ovum from individual with NLRP7 or KHDC3L
  • Dispermic PHM = 69XXY
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