Endocrine Control Female Reproduction 3 Flashcards

Summarize the gonadotropin releasing hormone regulation of gonadotropin secretion.

1
Q

What are some regulators of GnRH pulse frequency.

A
  • dopamine
  • serotonin
  • opioids
  • GABA
  • glutamate
  • NPY
  • norepinephrine
  • corticotrophin releasing hormone (CRH)
  • leptin
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2
Q

Describe the pulsatile nature of GnRH secretion.

A
  • Pulse generator
    • endogenous pulse frequency in humans is 1 pulse/hour
    • pulses necessary to maintain gonadotrope responsiveness to GnRH
    • continuous GnRH delivery suppresses gonadotropin secretion
  • Puberty
    • sleep entrained onset of pulsatile GnRH secretion
    • CNS restraint of GnRH release before puberty
  • GnRH pulse frequency
    • fast GnRH frequency increases LH
    • slow GnRH pulse frequency selectively increases FSH release
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