Type II Immunopathology - Autoimmunity Flashcards

1
Q

Describe the pathology of Graves disease.

A

Antibodies act as agonists on the thyroid-stimulating hormone receptor, driving high levels of thyroid hormone.

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2
Q

Type I immunopathology is _______.

A

mediated by IgE

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3
Q

Type II immunpathology is ________.

A

mediated by IgA, IgG, and IgM

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4
Q

Type III immunopathology is _________.

A

complexes of antibodies getting stuck in basement membranes, leading to vasculitis

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5
Q

Type IV immunopathology is ___________.

A

T cell mediated

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6
Q

Type V immunopathology (now a subset of type II) is _________.

A

when antibody binds to surface receptors

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7
Q

Goodpasture syndrome results from ___________.

A

antibodies that attack the basement membrane of the renal tubules and the alveolae

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8
Q

Idiopathic thrombocytopenia is know known to be _______.

A

autoimmune-mediated, as antibodies (usually after an infection) opsonize platelets; can be alleviated by immunosuppression or splenectomy

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9
Q

Autoimmune hypothyroidism is known as ________.

A

Hashimoto’s (caused by antibodies to necessary thyroid components)

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10
Q

Explain one mechanism by which B cells might be able to make antigen to self.

A

A B cell might be able to bind to a foreign protein attached to self protein (by binding its IgD to the self part) and then presenting

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