Type II Immunopathology - Autoimmunity Flashcards
Describe the pathology of Graves disease.
Antibodies act as agonists on the thyroid-stimulating hormone receptor, driving high levels of thyroid hormone.
Type I immunopathology is _______.
mediated by IgE
Type II immunpathology is ________.
mediated by IgA, IgG, and IgM
Type III immunopathology is _________.
complexes of antibodies getting stuck in basement membranes, leading to vasculitis
Type IV immunopathology is ___________.
T cell mediated
Type V immunopathology (now a subset of type II) is _________.
when antibody binds to surface receptors
Goodpasture syndrome results from ___________.
antibodies that attack the basement membrane of the renal tubules and the alveolae
Idiopathic thrombocytopenia is know known to be _______.
autoimmune-mediated, as antibodies (usually after an infection) opsonize platelets; can be alleviated by immunosuppression or splenectomy
Autoimmune hypothyroidism is known as ________.
Hashimoto’s (caused by antibodies to necessary thyroid components)
Explain one mechanism by which B cells might be able to make antigen to self.
A B cell might be able to bind to a foreign protein attached to self protein (by binding its IgD to the self part) and then presenting