CLL and Non-Hodgkin Lymphoma Flashcards
What are the three B cell markers?
CD19, CD20, and CD22
The most common leukemia in the western world is ______.
chronic lymphocytic leukemia
CLL is defined as ______.
> 5 x 10^9 lymphocytes per liter for greater than three months
CLL has a median age of presentation of ______ and is twice as common in _____.
65 years; men
Most CLL patients display ______.
mild symptoms or no symptoms at all
CLL cells present as ________.
high N:C ratio, small, condensed chromatin
Follicular lymphoma is defined as ______.
neoplasm of germinal B cell origin
Follicular lymphoma has a _____ incidence in men and women and a median age of presentation of _____.
equal; 60 years
Follicular lymphoma is often caused by the ______ translocation.
t (14;18)
______ is a diagnostic test for follicular lymphoma.
BCL2 (when positive in germinal B cells)
Mantle cells surround ______.
germinal centers
Mantle cell lymphomas typically express _______, but do not express ______.
CD5, CD19, and CD20; CD23 and cyclin D1 (BCL1)
Mantle cell lymphomas are _____ as common in men and have a median age of presentation of ______.
twice; 60 years
List the three common Burkitt lymphoma populations.
Endemic (in the malaria belt, among children, typically jaw and abdomen), sporadic (children or young adults, jaw or abdomen), and immunodeficiency-associated (HIV)
Burkitt lymphoma arises from _________.
germinal B cells
CLL is defined as an absolute lymphocyte count > ________.
5x10^9 for thee months
The most common genetic finding in CLL is ______.
del(13q14)
BCL6 and CD10 are two markers of _______.
germinal B cells and their derivative malignancies
Burkitt lymphoma has the “______” appearance with ________ cytoplasm.
starry-sky; basophilic
In _________, there is a complete effacement of lymph-node architecture.
diffuse large B cell lymphoma
Rouleaux formations are seen in _________.
myelomas
When lymph malignancies are positive for CD15 and CD30, what should you be thinking?
Hodgkin’s
