CLL and Non-Hodgkin Lymphoma

Question 1

What are the three B cell markers?

Answer 1

CD19, CD20, and CD22

Question 2

The most common leukemia in the western world is ______.

Answer 2

chronic lymphocytic leukemia

Question 3

CLL is defined as ______.

Answer 3

> 5 x 10^9 lymphocytes per liter for greater than three months

Question 4

CLL has a median age of presentation of ______ and is twice as common in _____.

Answer 4

65 years; men

Question 5

Most CLL patients display ______.

Answer 5

mild symptoms or no symptoms at all

Question 6

CLL cells present as ________.

Answer 6

high N:C ratio, small, condensed chromatin

Question 7

Follicular lymphoma is defined as ______.

Answer 7

neoplasm of germinal B cell origin

Question 8

Follicular lymphoma has a _____ incidence in men and women and a median age of presentation of _____.

Answer 8

equal; 60 years

Question 9

Follicular lymphoma is often caused by the ______ translocation.

Answer 9

t (14;18)

Question 10

______ is a diagnostic test for follicular lymphoma.

Answer 10

BCL2 (when positive in germinal B cells)

Question 11

Mantle cells surround ______.

Answer 11

germinal centers

Question 12

Mantle cell lymphomas typically express _______, but do not express ______.

Answer 12

CD5, CD19, and CD20; CD23 and cyclin D1 (BCL1)

Question 13

Mantle cell lymphomas are _____ as common in men and have a median age of presentation of ______.

Answer 13

twice; 60 years

Question 14

List the three common Burkitt lymphoma populations.

Answer 14

Endemic (in the malaria belt, among children, typically jaw and abdomen), sporadic (children or young adults, jaw or abdomen), and immunodeficiency-associated (HIV)

Question 15

Burkitt lymphoma arises from _________.

Answer 15

germinal B cells

Question 16

CLL is defined as an absolute lymphocyte count > ________.

Answer 16

5x10^9 for thee months

Question 17

The most common genetic finding in CLL is ______.

Answer 17

del(13q14)

Question 18

BCL6 and CD10 are two markers of _______.

Answer 18

germinal B cells and their derivative malignancies

Question 19

Burkitt lymphoma has the “______” appearance with ________ cytoplasm.

Answer 19

starry-sky; basophilic

Question 20

In _________, there is a complete effacement of lymph-node architecture.

Answer 20

diffuse large B cell lymphoma

Question 21

Rouleaux formations are seen in _________.

Answer 21

myelomas

Question 22

When lymph malignancies are positive for CD15 and CD30, what should you be thinking?

Answer 22

Hodgkin’s