Immunogenetics and Transplantation

Question 1

The most important loci within the HLA loci are ________.

Answer 1

HLA-A, HLA-B (both of which are MHC II), and HLA-DR (MHC I)

Question 2

The MHC set that you inherit from one parent is called a ______.

Answer 2

haplotype

Question 3

In an MLR reaction, the _______ cells are treated to prevent division.

Answer 3

donor’s (because we just want to see if the recipients T cells will divide in response to the donor’s MHC)

Question 4

Because of H-Y, _____ grafts will be rejected by ________.

Answer 4

male; females

Question 5

Allografts are ___________.

Answer 5

transplants between non-identical members of the same species.

Question 6

Xenografts are _____________.

Answer 6

transplants between members of different species

Question 7

Isografts are _________.

Answer 7

grafts between identical twins

Question 8

Autografts are __________.

Answer 8

transplants within the same individual

Question 9

CTLs require both _____ and ____ to become activated.

Answer 9

IL-2; foreign cells/infected cells

Question 10

Why is a good class II MHC activation important in a foreign-body situation?

Answer 10

Because class II activation (in Th1 cells) releases IL-2, an attractant for CTLs, and IFN-gamma, an attractant for macrophages