Immunology of AIDS Flashcards
Pneumocystis carinii pneumonia (PCP) is now called __________.
pneumocystis jirovecii pneumonia
Those without __________ are not able to be infected with HIV.
CCR52
The normal range of CD4+ T cells in the serum is ________; falling below ______ is diagnostic of AIDS.
500 - 1,000 / uL; 200 / uL
The pandemic form of HIV is type ________.
1; type 2 has not spread beyond west Africa
Because they cause slow, degenerative illness, the group of viruses of which HIV is a member are termed _________.
lentiviruses
Why is HIV so antigenically variable?
Because the reverse transcriptase enzyme that it uses is highly error prone
Those who can be infected with HIV but not symptomatic lack ________.
the CCR5 chemokine receptor
Elite controllers possess the _________.
HLA-B57 allele, which allows them to make CTLs against HIV
Infected people initially develop antibodies to HIV, which peak at ________; later these drop to the “set point,” a level of antibody determined by the host’s immune system.
six weeks
______ binds to the CCR5 receptor.
GP120
_____ forms the pore through which HIV’s RNA travels.
GP41
The normal CD4:CD8 ratio is ________.
1.5 - 3.0
How can HIV pass from cell to cell without an extracellular stage?
The virus causes cells to produce GP120 and GP41 on the surface of CD4 cells, and those proteins have a syncytial effect.
HIV hides dormant in ________.
Tfh
There are two kinds of reverse transcriptase inhibitors: ________.
nucleosides and non-nucleosides
