Plasma Cell Disorders and Hodgkin Lymphoma Flashcards
Most plasma cell neoplasms originate as ______, but some can be ______.
bone marrow tumors; extramedullary tumors
Explain the “CRAB” mnemonic.
In plasma cell myeloma, people usually have hyperCalcemia, Renal insufficiency, Anemia, and Bone lytic lesions.
What are the presenting signs of plasma cell myeloma?
Median age of 68; bone pain, CRAB
What immunoglobulin isotypes are typically found in PCM?
IgG (50%) and IgA (20%)
What is the gold standard test for PCM?
Serum/urine electrophoresis (to detect expanded gamma regions)
Kappa and lambda are types of _______.
light chains
In urine electrophoresis, only the _______ chain will be detected.
light (kappa or lambda)
Plasma cells have an ______ shape.
ovoid
In roughly ______ percent of patients with PCM, plasma cells will be detected in the peripheral blood.
15
Under peripheral smear, PCM presents with __________.
nucleoli in plasma cells (which aren’t usually present) and Rouleaux formation (clumped RBCs because RBCs are negative and Ig is positive)
In normal bone marrow smears, there will be about ___ percent plasma cells.
1% (PCM presents with much more)
MGUS (monoclonal gammopathy of undetermined significance) is essentially _______.
plasma cell myeloma without evidence of tumors, lytic bone lesions, and bone marrow plasma cells
What is the presentation of solitary plasmacytoma?
Single bone lesion of monoclonal plasma cells without other signs of PCM (i.e., no CRA)
Plasma cell masses found outside of the bone marrow are called ________.
extraosseous plasmacytoma (very rare)
Describe classical Hodgkin’s.
Malignant cells represent
