Spondyloarthropathies Flashcards
Spondyloarthropathies are asociated with the _______ allele.
HLA-B27
There are five classes of spondyloarthropathies: ___________.
ankylosing, psoriatic, reactive, regional (Crohn’s), and undifferentiated
Ankylosing spondyloarthritis is more common in ______.
males, caucasians, and younger onset patients
Those with AS have ________ and pain usually ______ with activity.
prolonged morning stiffness; decreases
Comorbidities of ankylosing spondylitis are ________.
anterior uveitis, osteoporosis, Crohn’s-like lesions, pulmonary fibrosis
Lab findings in ankylosing spondylitis are __________.
negative rheumatoid factor and negative anti-nuclear antibodies
Bone growths that grow together are called __________.
syndesmophytes
Reactive arthritis is usually preceded by ____________.
diarrheal or urethral infections with chlamydia, shigella, campylobacter, or yersinia
Reactive arthritis includes back pain similar to AS, but patients also can have ___________.
arthritis of the lower extremities, including of the toes (“sausage digits”), usually in an asymmetric distribution
Extra-articular manifestations of reactive arthritis include ____________.
uveitis, mucosal lesions, and conjunctivitis
As in ankylosing spondylitis, those with reactive arthritis will have lab values of ___________.
negative anti-nuclear antibodies, negative rheumatoid factor, and elevated erythrocyte sedimentation rate
In addition to back symptoms, those with psoriatic arthritis can have involvement of the __________.
DIPs, PIPs, and MCPs (usually in an asymmetric pattern)
The etiology of ankylosing spondylitis is unknown, but some have proposed the aggrecans hypothesis, which posits that ________.
aggrecans released by the destruction of cartilage leads to the abnormal activation of CD8+ T cells
